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Article

Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Level as a Predictor of the Severity of Community-Acquired Pneumonia

1
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
2
Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan
3
Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan
4
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
5
Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
7
Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
8
Department of Beauty Science, National Taichung University of Science and Technology, Taichung 404, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(6), 1035; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061035
Received: 15 February 2019 / Revised: 11 March 2019 / Accepted: 20 March 2019 / Published: 21 March 2019
(This article belongs to the Special Issue Current Perspectives in Respiratory Diseases)
The urokinase-type plasminogen activator receptor (uPAR) mediates various cellular activities and is involved in proteolysis, angiogenesis, and inflammation. The objective of this study was to investigate the association between soluble uPAR (suPAR) levels and community-acquired pneumonia (CAP) severity. A commercial enzyme-linked immunosorbent assay (ELISA) was performed to measure the plasma suPAR levels in 67 healthy controls and 75 patients with CAP. Our results revealed that plasma suPAR levels were significantly elevated in patients with CAP compared with the controls, and antibiotic treatment was effective in reducing suPAR levels. The plasma suPAR levels were correlated with the severity of CAP based on the pneumonia severity index (PSI) scores. Furthermore, lipopolysaccharide (LPS)-stimulation significantly increased uPAR expression in RAW 264.7 macrophages. In conclusion, plasma suPAR levels may play a role in the clinical assessment of CAP severity; these findings may provide information on new targets for treatment of CAP. View Full-Text
Keywords: community-acquired pneumonia; suPAR; LPS; pneumonia severity index community-acquired pneumonia; suPAR; LPS; pneumonia severity index
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MDPI and ACS Style

Tsai, P.-K.; Tsao, S.-M.; Yang, W.-E.; Yeh, C.-B.; Wang, H.-L.; Yang, S.-F. Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Level as a Predictor of the Severity of Community-Acquired Pneumonia. Int. J. Environ. Res. Public Health 2019, 16, 1035. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061035

AMA Style

Tsai P-K, Tsao S-M, Yang W-E, Yeh C-B, Wang H-L, Yang S-F. Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Level as a Predictor of the Severity of Community-Acquired Pneumonia. International Journal of Environmental Research and Public Health. 2019; 16(6):1035. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061035

Chicago/Turabian Style

Tsai, Ping-Kun, Shih-Ming Tsao, Wei-En Yang, Chao-Bin Yeh, Hsiang-Ling Wang, and Shun-Fa Yang. 2019. "Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Level as a Predictor of the Severity of Community-Acquired Pneumonia" International Journal of Environmental Research and Public Health 16, no. 6: 1035. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061035

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