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Article

Impact of Gender and Age on Rapid Eye Movement-Related Obstructive Sleep Apnea: A Clinical Study of 3234 Japanese OSA Patients

1
Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan
2
Biostatistics Center, Graduate School of Medicine, Kurume University, 67 Asahimachi, Kurume, Fukuoka 8300011, Japan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(6), 1068; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061068
Received: 14 February 2019 / Revised: 20 March 2019 / Accepted: 21 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Sleep Apnea Syndrome)
Rapid eye movement (REM)-related obstructive sleep apnea (OSA) is characterized by apnea and hypopnea events due to airway collapse occurring predominantly or exclusively during REM sleep. Previous studies have reported that REM-related OSA occurs more commonly in women and younger individuals. However, external validity of this tendency has not been confirmed in a large clinical sample. The objective of this study was to evaluate the effect of gender and age on REM-related OSA after adjustment for several covariates based on their established clinical relationships to gender difference in OSA. A total of 3234 Japanese patients with OSA were enrolled in this study. We confirmed that female sex is an important risk factor for REM-related OSA, as reported by previous studies. Moreover, we showed that women aged over 50 years were at a greater risk than those aged under 50 years. These results suggest that hormonal changes in women might play an important role in REM-related OSA and might reflect its unknown pathophysiological characteristics. View Full-Text
Keywords: obstructive sleep apnea; rapid eye movement-related obstructive sleep apnea; female sex hormone obstructive sleep apnea; rapid eye movement-related obstructive sleep apnea; female sex hormone
MDPI and ACS Style

Mano, M.; Hoshino, T.; Sasanabe, R.; Murotani, K.; Nomura, A.; Hori, R.; Konishi, N.; Baku, M.; Shiomi, T. Impact of Gender and Age on Rapid Eye Movement-Related Obstructive Sleep Apnea: A Clinical Study of 3234 Japanese OSA Patients. Int. J. Environ. Res. Public Health 2019, 16, 1068. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061068

AMA Style

Mano M, Hoshino T, Sasanabe R, Murotani K, Nomura A, Hori R, Konishi N, Baku M, Shiomi T. Impact of Gender and Age on Rapid Eye Movement-Related Obstructive Sleep Apnea: A Clinical Study of 3234 Japanese OSA Patients. International Journal of Environmental Research and Public Health. 2019; 16(6):1068. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061068

Chicago/Turabian Style

Mano, Mamiko, Tetsuro Hoshino, Ryujiro Sasanabe, Kenta Murotani, Atsuhiko Nomura, Reiko Hori, Noriyuki Konishi, Masayo Baku, and Toshiaki Shiomi. 2019. "Impact of Gender and Age on Rapid Eye Movement-Related Obstructive Sleep Apnea: A Clinical Study of 3234 Japanese OSA Patients" International Journal of Environmental Research and Public Health 16, no. 6: 1068. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16061068

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