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Article

The Effects of Short-Term Immunosuppressive Therapy on Redox Parameters in the Livers of Pregnant Wistar Rats

1
Department of Histology and Embryology, Pomeranian Medical University in Szczecin, Powst. Wlkp. 72, 70-111 Szczecin, Poland
2
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Powst. Wlkp. 72, 70-111 Szczecin, Poland
3
Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(8), 1370; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16081370
Received: 5 March 2019 / Revised: 12 April 2019 / Accepted: 14 April 2019 / Published: 16 April 2019
Immunosuppressive drugs are widely used to avoid graft rejection, but they are also known to be strongly hepatotoxic. The goal of the current study was to determine: (i) the immunoexpression of SOD1, CAT, GPX1; (ii) the concentration of MDA, GSH; (iii) the activity of SOD, CAT, GPX, in the native liver of a pregnant female rats undergoing immunosuppressive therapy. The study was based on archival material obtained from Department of Nephrology, Transplantology and Internal Medicine of the Independent Public Clinical Hospital No. 2 at the Pomeranian Medical University in Szczecin, Poland. The study was carried out on 32 female rats exposed to oral administration of immunosuppressants two weeks before and during pregnancy. The percentage of SOD1 immunopositive hepatocytes in rats treated with cyclosporine A, mycophenolate mofetil, everolimus, and glucocorticosteroid was significantly elevated above that of the control rats. The concentration of MDA in the liver of animals exposed to cyclosporine A, everolimus, and glucocorticosteroid was significantly higher than in other groups. Among the groups of dams treated with immunosuppressive drugs, the highest significant concentration of GSH was found in the livers of rats treated with cyclosporine A, mycophenolate mofetil and glucocorticosteroid. Immunosuppressive therapy during pregnancy affects the oxidoreductive balance in the livers of rats, depending on the regimen used. View Full-Text
Keywords: oxidative stress; immunosuppressive drugs; liver; transplantation; pregnancy; redox balance oxidative stress; immunosuppressive drugs; liver; transplantation; pregnancy; redox balance
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MDPI and ACS Style

Szypulska-Koziarska, D.; Wilk, A.; Kabat-Koperska, J.; Kolasa-Wołosiuk, A.; Wolska, J.; Wiszniewska, B. The Effects of Short-Term Immunosuppressive Therapy on Redox Parameters in the Livers of Pregnant Wistar Rats. Int. J. Environ. Res. Public Health 2019, 16, 1370. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16081370

AMA Style

Szypulska-Koziarska D, Wilk A, Kabat-Koperska J, Kolasa-Wołosiuk A, Wolska J, Wiszniewska B. The Effects of Short-Term Immunosuppressive Therapy on Redox Parameters in the Livers of Pregnant Wistar Rats. International Journal of Environmental Research and Public Health. 2019; 16(8):1370. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16081370

Chicago/Turabian Style

Szypulska-Koziarska, Dagmara, Aleksandra Wilk, Joanna Kabat-Koperska, Agnieszka Kolasa-Wołosiuk, Jolanta Wolska, and Barbara Wiszniewska. 2019. "The Effects of Short-Term Immunosuppressive Therapy on Redox Parameters in the Livers of Pregnant Wistar Rats" International Journal of Environmental Research and Public Health 16, no. 8: 1370. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16081370

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