Next Article in Journal
Marine Predators Algorithm for Forecasting Confirmed Cases of COVID-19 in Italy, USA, Iran and Korea
Next Article in Special Issue
Quality of Life and Coping in Nonalcoholic Fatty Liver Disease: Influence of Diabetes and Obesity
Previous Article in Journal
The Effects of Psychological Factors on Perceptions of Productivity in Construction Sites in Japan by Worker Age
Article

Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population

1
Preventive Medicine Department, Virgen de la Victoria University Hospital, 29010 Malaga, Spain
2
Internal Medicine Department, Regional University Hospital of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Malaga, Spain
3
Ciber Fisiopatología de la Obesidad y Nutrición. Instituto de Salud Carlos III, 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3518; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103518
Received: 13 April 2020 / Revised: 11 May 2020 / Accepted: 14 May 2020 / Published: 18 May 2020
The aim of this study was to analyze the utility of liver function tests (LFT) and fatty liver index (FLI), a surrogate marker of non-alcoholic fatty liver disease, in the categorization of metabolic phenotypes in a Mediterranean population. A cross-sectional study was performed on a random representative sample of 2233 adults assigned to a health center in Málaga, Spain. The metabolic phenotypes were determined based on body mass index (BMI) categorization and the presence or absence of two or more cardiometabolic abnormalities (high blood pressure, low high-density lipoprotein (HDL) cholesterol, hypertriglyceridemia, pre-diabetes) or type 2 diabetes. No difference was observed between metabolically healthy and metabolically abnormal phenotypes on LFT. The mean FLI of the population was 41.1 ± 28.6. FLI was significantly higher (p < 0.001) in the metabolically abnormal phenotypes in all BMI categories. The proportion of individuals with pathological FLI (≥60) was significantly higher in the metabolically abnormal overweight and obese phenotypes (p < 0.001). On a multivariate model adjusted for sex, age, and waist circumference, a significant correlation was found between pathological FLI and metabolically abnormal phenotypes in the overweight and obese BMI categories. Area under the curve (AUC) of FLI as a biomarker was 0.76, 0.74, and 0.72 for the metabolically abnormal normal-weight, overweight, and obese groups, respectively. Liver biochemistry is poorly correlated with metabolic phenotypes. Conversely, a good correlation between FLI, as a marker of non-alcoholic fatty liver disease (NAFLD), and metabolically abnormal phenotypes in all BMI ranges was found. Our study suggests that FLI may be a useful marker for characterizing metabolically abnormal phenotypes in individuals who are overweight or obese. View Full-Text
Keywords: Non-alcoholic fatty liver disease; body mass index; lipids; diabetes Non-alcoholic fatty liver disease; body mass index; lipids; diabetes
Show Figures

Figure 1

MDPI and ACS Style

Narankiewicz, D.; Ruiz-Nava, J.; Buonaiuto, V.; Ruiz-Moreno, M.I.; López-Carmona, M.D.; Pérez-Belmonte, L.M.; Gómez-Huelgas, R.; Bernal-López, M.R. Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population. Int. J. Environ. Res. Public Health 2020, 17, 3518. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103518

AMA Style

Narankiewicz D, Ruiz-Nava J, Buonaiuto V, Ruiz-Moreno MI, López-Carmona MD, Pérez-Belmonte LM, Gómez-Huelgas R, Bernal-López MR. Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population. International Journal of Environmental Research and Public Health. 2020; 17(10):3518. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103518

Chicago/Turabian Style

Narankiewicz, Dariusz, Josefina Ruiz-Nava, Veronica Buonaiuto, María I. Ruiz-Moreno, María D. López-Carmona, Luis M. Pérez-Belmonte, Ricardo Gómez-Huelgas, and María R. Bernal-López 2020. "Utility of Liver Function Tests and Fatty Liver Index to Categorize Metabolic Phenotypes in a Mediterranean Population" International Journal of Environmental Research and Public Health 17, no. 10: 3518. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103518

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop