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Article

A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial

1
Department of Pediatrics, Hospital Group Twente, 7609 PP Almelo, The Netherlands
2
Faculty of Behavioural, Management and Social Sciences (BMS), University of Twente, 7522 NB Enschede, The Netherlands
3
Department of Pediatrics, Medical Centre Twente, 7512 KZ Enschede, The Netherlands
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3689; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103689
Received: 3 May 2020 / Revised: 21 May 2020 / Accepted: 22 May 2020 / Published: 23 May 2020
Purpose: Subclinical hypothyroidism (SH) in children and adults is a subject for discussion in terms of whether to treat it or not with respect to the short-term clinical implications and consequences of SH and in the long term. If treatment with thyroxine supplementation is not indicated, no other treatment is available. We investigated whether a lifestyle (dietary) intervention improves or normalizes SH or decreases the presence of Thyroid Stimulating Hormone (TSH) and/or tiredness. Methods: We randomized children aged 1–12 years with SH to the control group (standard care = no treatment) or intervention group (dietary intervention). The dietary intervention consisted of green vegetables, beef, whole milk and butter for 6 months. The rest of the diet remained unchanged. We measured TSH, FreeT4, Lipid profile, Body Mass Index (BMI) and Pediatric Quality of Life (PedQL) multidimensional fatigue scale scores. Results: In total, 62 children were included. After 6 months, TSH decreased in both groups without a significant difference between the groups (p = 0.98). PedQL fatigue scores for sleep (p = 0.032) and total fatigue scores (p = 0.039) improved significantly in the intervention group, compared to the control group. No unfavorable effects occurred in the lipid profile or BMI. Conclusion: The lifestyle (dietary) intervention did not normalize SH and TSH levels, but it significantly reduced tiredness. These results suggest that children’s well-being can be improved without medication. View Full-Text
Keywords: subclinical hypothyroidism; tiredness; fatigue; lifestyle; dietary intervention; beef; vegetables; whole dairy products subclinical hypothyroidism; tiredness; fatigue; lifestyle; dietary intervention; beef; vegetables; whole dairy products
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MDPI and ACS Style

van der Gaag, E.; van der Palen, J.; Schaap, P.; van Voorthuizen, M.; Hummel, T. A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial. Int. J. Environ. Res. Public Health 2020, 17, 3689. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103689

AMA Style

van der Gaag E, van der Palen J, Schaap P, van Voorthuizen M, Hummel T. A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial. International Journal of Environmental Research and Public Health. 2020; 17(10):3689. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103689

Chicago/Turabian Style

van der Gaag, Ellen, Job van der Palen, Pim Schaap, Mirthe van Voorthuizen, and Thalia Hummel. 2020. "A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial" International Journal of Environmental Research and Public Health 17, no. 10: 3689. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17103689

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