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Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
Department of Pediatrics, Chiayi Chang Gung Memorial Hospital, Chiayi 613016, Taiwan
Beijing Institute of Technology, School of Life Science, Beijing 100081, China
KU School of Nursing, Nursing Associate Tech Adult Inpatient Psych KU Strawberry Hill Campus, Kansas City, KS 66101, USA
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kaohsiung 83301, Taiwan
Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 83301, Taiwan
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3726;
Received: 27 March 2020 / Revised: 20 May 2020 / Accepted: 22 May 2020 / Published: 25 May 2020
(This article belongs to the Special Issue Children's Environmental Health)
The risk of ethnic Kawasaki disease (KD) has been proposed to be associated with blood mercury levels in American children. We investigated the blood levels of mercury in children with KD and their association with disease outcome. The mercury levels demonstrated a significantly negative correlation with sodium levels (p = 0.007). However, data failed to reach a significant difference after excluding the child with blood mercury exceeding the toxic value. The findings indicate that KD patients with lower sodium concentrations had a remarkably higher proportion of intravenous immunoglobulin (IVIG) resistance (p = 0.022). Our patients who had lower mercury levels (<0.5 μg/L) had more changes in bacille Calmette-Guerin. Mercury levels in 14/14 patients with coronary artery lesions and 4/4 patients with IVIG resistance were all measured to have values greater than 1 μg/L (while average values showed 0.92 μg/L in Asian American children). Mercury levels had no correlations with IVIG resistance or coronary artery lesion (CAL) formation (p > 0.05). CAL development was more common in the incomplete group than in the complete KD group (p = 0.019). In this first report about mercury levels in KD patients, we observed that the juvenile Taiwanese had higher mercury concentration in blood compared to other populations. View Full-Text
Keywords: Kawasaki disease; mercury; sodium Kawasaki disease; mercury; sodium
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MDPI and ACS Style

Chang, L.-S.; Yan, J.-H.; Li, J.-Y.; Yeter, D.D.; Huang, Y.-H.; Guo, M.M.-H.; Lo, M.-H.; Kuo, H.-C. Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome. Int. J. Environ. Res. Public Health 2020, 17, 3726.

AMA Style

Chang L-S, Yan J-H, Li J-Y, Yeter DD, Huang Y-H, Guo MM-H, Lo M-H, Kuo H-C. Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome. International Journal of Environmental Research and Public Health. 2020; 17(10):3726.

Chicago/Turabian Style

Chang, Ling-Sai, Jia-Huei Yan, Jin-Yu Li, Deniz D. Yeter, Ying-Hsien Huang, Mindy M.-H. Guo, Mao-Hung Lo, and Ho-Chang Kuo. 2020. "Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome" International Journal of Environmental Research and Public Health 17, no. 10: 3726.

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