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Article

Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data

1
CIRFF, Center of Pharmacoeconomics and Drug utilization Research, University of Naples Federico II, 80131 Naples, Italy
2
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy
3
Regional Pharmaceutical Unit, Campania Region, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(11), 3926; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17113926
Received: 19 April 2020 / Revised: 20 May 2020 / Accepted: 28 May 2020 / Published: 1 June 2020
A gender-specific drug utilization study was performed in the Campania region, Southern Italy. Data were based on outpatient drug prescriptions collected from administrative databases. The study population included all patients with at least one drug prescription in 2018. Prevalence was used as a measure to estimate the degree of exposure to drugs. A total of 3,899,360 patients were treated with at least one drug (54.2% females). The number of prescriptions was higher in females than males (55.6% vs. 44.4%). Females recorded higher prevalence for the majority of therapeutic groups (ATC II—anatomical therapeutic chemical), as well as for anti-inflammatory and antirheumatic products drugs (M01) (25.6% vs. 18.7%, risk ratio (RR): 0.73), beta blocking agents (C07) (14.5% vs. 11.6%, RR: 0.80), psychoanaleptics (N06) (7.1% vs. 3.7%, RR: 0.52), and antianemic preparations (B03) (2.8% vs. 6.7%, RR: 0.4). Higher prevalence was identified for males only for drugs used in diabetes (A10) (6.8% vs. 6.2%, RR: 1.1), particularly for biguanides (A10BA). Conversely, treatment duration was longer among males, explaining the higher mean cost per treated patient. This real-world study showed substantial gender differences in terms of medication use and duration of treatment and costs. These results are relevant to promoting and supporting the emerging role of precision and personalized medicine. View Full-Text
Keywords: gender difference; real-world data; drug utilization study; prescription pattern; medication use; drug cost gender difference; real-world data; drug utilization study; prescription pattern; medication use; drug cost
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MDPI and ACS Style

Orlando, V.; Mucherino, S.; Guarino, I.; Guerriero, F.; Trama, U.; Menditto, E. Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data. Int. J. Environ. Res. Public Health 2020, 17, 3926. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17113926

AMA Style

Orlando V, Mucherino S, Guarino I, Guerriero F, Trama U, Menditto E. Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data. International Journal of Environmental Research and Public Health. 2020; 17(11):3926. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17113926

Chicago/Turabian Style

Orlando, Valentina, Sara Mucherino, Ilaria Guarino, Francesca Guerriero, Ugo Trama, and Enrica Menditto. 2020. "Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data" International Journal of Environmental Research and Public Health 17, no. 11: 3926. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17113926

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