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Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

1
Tissue Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia
2
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(11), 4160; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17114160
Received: 25 March 2020 / Revised: 15 April 2020 / Accepted: 18 April 2020 / Published: 11 June 2020
(This article belongs to the Section Health Care Sciences & Services)
Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process. View Full-Text
Keywords: Nigella sativa; thymoquinone; skin wound healing; anti-inflammatory; antioxidant; antibacterial Nigella sativa; thymoquinone; skin wound healing; anti-inflammatory; antioxidant; antibacterial
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MDPI and ACS Style

Sallehuddin, N.; Nordin, A.; Bt Hj Idrus, R.; Fauzi, M.B. Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review. Int. J. Environ. Res. Public Health 2020, 17, 4160. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17114160

AMA Style

Sallehuddin N, Nordin A, Bt Hj Idrus R, Fauzi MB. Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review. International Journal of Environmental Research and Public Health. 2020; 17(11):4160. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17114160

Chicago/Turabian Style

Sallehuddin, Nusaibah, Abid Nordin, Ruszymah Bt Hj Idrus, and Mh B. Fauzi 2020. "Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review" International Journal of Environmental Research and Public Health 17, no. 11: 4160. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17114160

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