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Article

Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data

1
Department of Oral & Maxillofacial Surgery, Dentistry, Hallym University College of Medicine, Anyang 14068, Korea
2
Institute of Clinical Dentistry, Hallym University, Chuncheon 24252, Korea
3
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
4
Department of Orthopedic Surgery, Hallym University College of Medicine, Anyang 14068, Korea
5
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Dongtan 14068, Korea
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(13), 4777; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17134777
Received: 5 June 2020 / Revised: 18 June 2020 / Accepted: 27 June 2020 / Published: 2 July 2020
(This article belongs to the Special Issue Influence of Risk Factors on Periodontitis and Periodontal Treatment)
Hyperuricemia arises from the buildup of excessive uric acid in the blood, and it is implicated in the development of periodontitis. The objective of this study was to investigate the association between hyperuricemia and periodontitis using a cross-sectional study design and Korean Genome and Epidemiology Study Health Examinee (KoGES HEXA) data. This prospective cohort study used epidemiological data from the KoGES from 2004 to 2016. Among 173,209 participants, 8809 with hyperuricemia and 126,465 controls (non-hyperuricemia) were selected. This study defined hyperuricemia as >7.0 mg/dL of uric acid in men and >6.0 mg/dL in women. This study analyzed the history of periodontitis among hyperuricemia and control participants. Participants’ age, gender, income, obesity, smoking, alcohol consumption, and nutritional intake were all examined. Chi-square tests, independent t-tests, and two-tailed analyses were used for statistical analysis. The adjusted OR (aOR) of hyperuricemia for periodontitis was 0.89 (95% confidence interval (CI) = 0.81–0.96, p = 0.005). This study demonstrated that hyperuricemia was associated with periodontitis. This finding meant that elevated uric acid levels could have a positive effect on periodontitis. However, further studies should be performed to determine the range of uric acid levels beneficial to periodontal health. View Full-Text
Keywords: periodontitis; hyperuricemia; osteoporosis; periodontal-systemic disease interactions periodontitis; hyperuricemia; osteoporosis; periodontal-systemic disease interactions
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MDPI and ACS Style

Byun, S.-H.; Yoo, D.-M.; Lee, J.-W.; Choi, H.-G. Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data. Int. J. Environ. Res. Public Health 2020, 17, 4777. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17134777

AMA Style

Byun S-H, Yoo D-M, Lee J-W, Choi H-G. Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data. International Journal of Environmental Research and Public Health. 2020; 17(13):4777. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17134777

Chicago/Turabian Style

Byun, Soo-Hwan, Dae-Myoung Yoo, Jung-Woo Lee, and Hyo-Geun Choi. 2020. "Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data" International Journal of Environmental Research and Public Health 17, no. 13: 4777. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17134777

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