Next Article in Journal
Why Do Some Spanish Nursing Students with Menstrual Pain Fail to Consult Healthcare Professionals?
Previous Article in Journal
Women’s Empowerment as a Mitigating Factor for Improved Antenatal Care Quality despite Impact of 2014 Ebola Outbreak in Guinea
Article

Dopamine Receptor D2 Gene (DRD2) Polymorphisms, Job Stress, and Their Interaction on Sleep Dysfunction

1
Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environment Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350012, China
2
Department of Occupational and Environmental Health, School of Public Health, Xinjiang Medical University, Urumqi 830001, China
3
Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong 226019, China
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(21), 8174; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17218174
Received: 21 October 2020 / Accepted: 3 November 2020 / Published: 5 November 2020
(This article belongs to the Section Occupational Safety and Health)
Recent studies have shown that incessant job stress could eventually result in sleep dysfunction (SD), and most importantly, the essential role dopamine receptor D2 (DRD2) gene polymorphisms play in the psychopathological mechanism of SD. The Effort-Reward Imbalance scale and the Pittsburgh Sleep Quality Index were both used to access SD and job stress (JS). A significant negative correlation was observed between the sDA levels and SD subscale scores (sleep efficiency, daytime dysfunction). The findings revealed that high levels of JS were linked to a higher SD score (OR = 2.13, 95% CI: 1.46–3.12). Likewise, the homozygous A1A1 genotype of DRD2 rs1800497 was more likely to be associated with SD (OR = 2.90, 95% CI: 1.75–4.82). Compared to participants with low JS and heterozygous A1A2/A2A2 genotype, those with both high JS and homozygous A1A1 genotype had a higher SD score (OR = 5.40, 95% CI: 2.89–10.11). The A1 allele of the DRD2 rs1800497 polymorphism also enhances the likelihood of SD when undergoing JS. Besides, subjects with low JS and the homozygous A1A1 genotype also showed an increased possibility for sleep dysfunction (OR = 2.05, 95% CI: 1.03–4.11). Our results suggest that the DA system may interrelate with JS to affect sleep. View Full-Text
Keywords: job stress; dopamine receptor D2 (DRD2); sleep dysfunction; gene-environment interaction; sDA job stress; dopamine receptor D2 (DRD2); sleep dysfunction; gene-environment interaction; sDA
MDPI and ACS Style

Jiang, Y.; Liu, B.; Wu, C.; Gao, X.; Lu, Y.; Lian, Y.; Liu, J. Dopamine Receptor D2 Gene (DRD2) Polymorphisms, Job Stress, and Their Interaction on Sleep Dysfunction. Int. J. Environ. Res. Public Health 2020, 17, 8174. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17218174

AMA Style

Jiang Y, Liu B, Wu C, Gao X, Lu Y, Lian Y, Liu J. Dopamine Receptor D2 Gene (DRD2) Polymorphisms, Job Stress, and Their Interaction on Sleep Dysfunction. International Journal of Environmental Research and Public Health. 2020; 17(21):8174. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17218174

Chicago/Turabian Style

Jiang, Yu, Baoying Liu, Chuancheng Wu, Xiaoyan Gao, Yaoqin Lu, Yulong Lian, and Jiwen Liu. 2020. "Dopamine Receptor D2 Gene (DRD2) Polymorphisms, Job Stress, and Their Interaction on Sleep Dysfunction" International Journal of Environmental Research and Public Health 17, no. 21: 8174. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17218174

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop