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Article

Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer

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Medical Oncology Service, Salamanca University Hospital, 37007 Salamanca, Spain
2
Nursing and Physiotherapy Department, University of Salamanca, 37007 Salamanca, Spain
3
Medicine Department, University of Salamanca, 37007 Salamanca, Spain
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(23), 8896; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17238896
Received: 9 October 2020 / Revised: 2 November 2020 / Accepted: 26 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Cognitive Empowerment for the Enhancement of Active and Healthy Aging)
Background: Oncology patients experience a large number of symptoms and, those referring to cognitive performance has an ever-increasing importance in clinical practice, due to the increase in survival rates and interest in the patient’s quality of life. The studies reviewed showed that chemotherapy-related cognitive impairment might occur in 15 and 50% of oncology patients. The main objective of this research was to study the impact of chemotherapy on the cognitive function of patients with locoregional breast cancer. Method: Analytical, prospective, longitudinal study using three measures, unifactorial intrasubject design, non-probability, and random selection sampling. The sample comprised women newly diagnosed with locoregional breast cancer in stages I, II, IIIA who received chemotherapy at the University Hospital of Salamanca (Complejo Asistencial Universitario de Salamanca), randomly selected for three years. Semi-structured interviews were conducted, and anxiety and depression (Hospital Anxiety and Depression scale, HAD); quality of life (QLQ-BR23 scale) and the following cognitive variables were assessed—processing speed, attention, memory, and executive functions (subtests of the Wechsler Intelligence Scale and the Trail Making Test). Results: The final sample size included 151 participants; 23 were excluded. A decline in cognitive performance was observed in patients, which did not completely recover two months after chemotherapy was completed. Additionally, worse cognitive performance was observed in patients with anxious or depressive symptoms. There was a negative impact on the quality of life. Conclusion: Chemotherapy had an impact on the cognitive performance of oncology patients in most cognitive domains studied. View Full-Text
Keywords: chemotherapy; cognitive impairment; cancer chemotherapy; cognitive impairment; cancer
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MDPI and ACS Style

Rodríguez Martín, B.; Fernández Rodríguez, E.J.; Rihuete Galve, M.I.; Cruz Hernández, J.J. Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer. Int. J. Environ. Res. Public Health 2020, 17, 8896. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17238896

AMA Style

Rodríguez Martín B, Fernández Rodríguez EJ, Rihuete Galve MI, Cruz Hernández JJ. Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer. International Journal of Environmental Research and Public Health. 2020; 17(23):8896. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17238896

Chicago/Turabian Style

Rodríguez Martín, Blanca, Eduardo J. Fernández Rodríguez, María I. Rihuete Galve, and Juan J. Cruz Hernández 2020. "Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer" International Journal of Environmental Research and Public Health 17, no. 23: 8896. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17238896

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