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Article

Real World Use of Antidiabetic Drugs in the Years 2011–2017: A Population-Based Study from Southern Italy

1
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy
2
Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
3
Palermo Local Health Unit, Department of Pharmacy, 90127 Palermo, Italy
4
Regional Referral Centre for Insulin Pump Implantation and Diabetes, Civic Hospital, Partinico, 90047 Palermo, Italy
5
Department of Epidemiologic Observatory, Health Department of Sicily, 90127 Palermo, Italy
6
Department of Diagnostic and Public Health, University of Verona, 37134 Verona, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(24), 9514; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249514
Received: 19 November 2020 / Revised: 15 December 2020 / Accepted: 16 December 2020 / Published: 18 December 2020
(This article belongs to the Special Issue Real-World Evidence in Clinical Epidemiology and Public Health)
Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. The availability of new antidiabetic drugs (ADs) has led to complex treatment patterns and to changes in the patterns of specific drug utilization. The aim of this population-based study was to describe the pattern of antidiabetic drugs (ADs) use in Southern Italy in the years 2011–2017, in relation to the updated type 2 diabetes mellitus (T2DM) therapy guidelines. A retrospective cohort study was conducted on T2DM patients using data from the Palermo Local Health Unit (LHU) claims database and diabetologist registry. The first-line treatment was investigated and incident treatments were identified and characterized at baseline in terms of demographics, complications, comorbidities, concomitant drugs and clinical parameters. Persistence to AD treatment was also evaluated. During the study period, one-third of first ever ADs users started the treatment with ADs other than metformin, in contrast to guideline recommendations. Among 151,711 incident AD treatments, the male to female ratio was 1.0 and the median age was 66 (57–75) years. More than half (55.0%) of incident treatments discontinued the therapy during the first year of treatment. In Italy, general practitioners (GPs) can only prescribe first-generation ADs, while the prescription of more recently marketed ADs, such as GLP-1RA, DPP4i and SGLT2i, is restricted to diabetologists only, based on a therapeutic plan. The role of GPs in the management of T2DM in Italy should be re-evaluated. View Full-Text
Keywords: antidiabetic drugs; real world data; type 2 diabetes mellitus; therapy guidelines; Southern Italy antidiabetic drugs; real world data; type 2 diabetes mellitus; therapy guidelines; Southern Italy
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MDPI and ACS Style

Ingrasciotta, Y.; Bertuccio, M.P.; Crisafulli, S.; Ientile, V.; Muscianisi, M.; L’Abbate, L.; Pastorello, M.; Provenzano, V.; Scorsone, A.; Scondotto, S.; Trifirò, G. Real World Use of Antidiabetic Drugs in the Years 2011–2017: A Population-Based Study from Southern Italy. Int. J. Environ. Res. Public Health 2020, 17, 9514. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249514

AMA Style

Ingrasciotta Y, Bertuccio MP, Crisafulli S, Ientile V, Muscianisi M, L’Abbate L, Pastorello M, Provenzano V, Scorsone A, Scondotto S, Trifirò G. Real World Use of Antidiabetic Drugs in the Years 2011–2017: A Population-Based Study from Southern Italy. International Journal of Environmental Research and Public Health. 2020; 17(24):9514. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249514

Chicago/Turabian Style

Ingrasciotta, Ylenia, Maria P. Bertuccio, Salvatore Crisafulli, Valentina Ientile, Marco Muscianisi, Luca L’Abbate, Maurizio Pastorello, Vincenzo Provenzano, Alessandro Scorsone, Salvatore Scondotto, and Gianluca Trifirò. 2020. "Real World Use of Antidiabetic Drugs in the Years 2011–2017: A Population-Based Study from Southern Italy" International Journal of Environmental Research and Public Health 17, no. 24: 9514. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249514

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