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Article

The Association between Nonalcoholic Fatty Liver Disease and Stroke: Results from the Korean Genome and Epidemiology Study (KoGES)

1
Institute of Biomedical Science, Catholic Kwandong University International St. Mary’s Hospital, Incheon 22711, Korea
2
Cardiovascular Center, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-Si 18450, Korea
3
Division of Gastroenterology, Department of Internal Medicine, Catholic Kwandong University International St. Mary’s Hospital, Incheon 22711, Korea
4
Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul 06974, Korea
5
Department of Neurology, Catholic Kwandong University International St. Mary’s Hospital, Incheon 22711, Korea
*
Author to whom correspondence should be addressed.
Yun-Jung Yang and Mi-Hyang Jung contributed equally to this work.
Int. J. Environ. Res. Public Health 2020, 17(24), 9568; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249568
Received: 2 December 2020 / Revised: 14 December 2020 / Accepted: 16 December 2020 / Published: 21 December 2020
(This article belongs to the Special Issue Big Data for Public Health Research and Practice)
(1) Background: Non-alcoholic fatty liver disease (NAFLD) is associated with various cardiometabolic diseases. However, the association between NAFLD and stroke is not well known. The purpose of our study is to reveal the relationship between NAFLD and Stroke incidence. (2) Methods: Using data from a Korean prospective cohort study, we excluded participants with heavy alcohol consumption and a history of stroke; hence, 7964 adults aged 40–69 years were included in this study. According to their fatty liver index (FLI), participants were divided into three groups: <30 (n = 4550, non-NAFLD), 30–59.9 (n = 2229, intermediate), and ≥60 (n = 1185, NAFLD). The incidence of stroke according to the degree of FLI was evaluated using the Cox proportional hazard model. (3) Results: During the 12-year follow-up period, 168 strokes occurred. A graded association between NAFLD and stroke incidence was observed, i.e., 1.7% (n = 76), 2.5% (n = 56), and 3.0% (n = 36) for non-NAFLD, intermediate, and NAFLD FLI groups, respectively. After adjusting for confounding variables and compared to the risk of stroke in the non-NAFLD group, the risk of stroke in the NAFLD group was the highest (hazard ratio [HR]: 1.98, 95% confidence interval [CI]: 1.17–3.34), followed by the risk of stroke in the intermediate group (HR: 1.41, 95% CI: 0.94–2.21) (p for trend < 0.001). However, the level of aspartate aminotransferase, alanine aminotransferase, or gamma-glutamyltransferase alone did not show any significant association with stroke. (4) Conclusions: This study demonstrated that the risk of stroke incidence gradually increased with the degree of FLI. Individuals with NAFLD should be properly counseled and monitored for risk for stroke. View Full-Text
Keywords: stroke; non-alcoholic fatty liver disease; incidence; risk factors; liver; cohort studies stroke; non-alcoholic fatty liver disease; incidence; risk factors; liver; cohort studies
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MDPI and ACS Style

Yang, Y.-J.; Jung, M.-H.; Jeong, S.-H.; Hong, Y.-P.; Kim, Y.I.; An, S.J. The Association between Nonalcoholic Fatty Liver Disease and Stroke: Results from the Korean Genome and Epidemiology Study (KoGES). Int. J. Environ. Res. Public Health 2020, 17, 9568. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249568

AMA Style

Yang Y-J, Jung M-H, Jeong S-H, Hong Y-P, Kim YI, An SJ. The Association between Nonalcoholic Fatty Liver Disease and Stroke: Results from the Korean Genome and Epidemiology Study (KoGES). International Journal of Environmental Research and Public Health. 2020; 17(24):9568. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249568

Chicago/Turabian Style

Yang, Yun-Jung, Mi-Hyang Jung, Seok-Hoo Jeong, Yeon-Pyo Hong, Yeong I. Kim, and Sang J. An 2020. "The Association between Nonalcoholic Fatty Liver Disease and Stroke: Results from the Korean Genome and Epidemiology Study (KoGES)" International Journal of Environmental Research and Public Health 17, no. 24: 9568. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17249568

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