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Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies

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Hubei Provincial Center for Disease Control and Prevention, 6 Zhuodaoquan North Road, Wuhan 430079, Hubei, China
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Department of Preventive Medicine, School of Health Sciences, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China
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Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(4), 1457; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17041457
Received: 3 December 2019 / Revised: 13 January 2020 / Accepted: 11 February 2020 / Published: 24 February 2020
Epidemiological studies on residential radon exposure and the risk of histological types of lung cancer have yielded inconsistent results. We conducted a meta-analysis on this topic and updated previous related meta-analyses. We searched the databases of Cochrane Library, Embase, PubMed, Web of Science and Chinese National Knowledge Infrastructure for papers published up to 13 November 2018. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed and random effects models. Subgroup and dose‒response analyses were also conducted. This study was registered with PROSPERO (No. CRD42019127761). A total of 28 studies, which included 13,748 lung cancer cases and 23,112 controls, were used for this meta-analysis. The pooled OR indicated that the highest residential radon exposure was significantly associated with an increased risk of lung cancer (OR = 1.48, 95% CI = 1.26–1.73). All histological types of lung cancer were associated with residential radon. Strongest association with small-cell lung carcinoma (OR = 2.03, 95% CI = 1.52–2.71) was found, followed by adenocarcinoma (OR = 1.58, 95% CI = 1.31–1.91), other histological types (OR = 1.54, 95% CI = 1.11–2.15) and squamous cell carcinoma (OR = 1.43, 95% CI = 1.18–1.74). With increasing residential radon levels per 100 Bq/m3, the risk of lung cancer, small-cell lung carcinoma and adenocarcinoma increased by 11%, 19% and 13%, respectively. This meta-analysis provides new evidence for a potential relationship between residential radon and all histological types of lung cancer. View Full-Text
Keywords: residential radon; lung cancer; histology; meta-analysis; case‒control study residential radon; lung cancer; histology; meta-analysis; case‒control study
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MDPI and ACS Style

Li, C.; Wang, C.; Yu, J.; Fan, Y.; Liu, D.; Zhou, W.; Shi, T. Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies. Int. J. Environ. Res. Public Health 2020, 17, 1457. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17041457

AMA Style

Li C, Wang C, Yu J, Fan Y, Liu D, Zhou W, Shi T. Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies. International Journal of Environmental Research and Public Health. 2020; 17(4):1457. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17041457

Chicago/Turabian Style

Li, Cong, Chunhong Wang, Jun Yu, Yongsheng Fan, Duanya Liu, Wenshan Zhou, and Tingming Shi. 2020. "Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies" International Journal of Environmental Research and Public Health 17, no. 4: 1457. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17041457

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