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Article

Periodontal Condition Is Correlated with Deep and Subcortical White Matter Hyperintensity Lesions in Japanese Adults

1
Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Gifu 501-0296, Japan
2
Department of Oral Health and Preventive Dentistry, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan
3
Asahi University Hospital, 3- 23 Hashimoto-cho, Gifu, Gifu 500-8523, Japan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(5), 1694; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17051694
Received: 31 January 2020 / Revised: 2 March 2020 / Accepted: 3 March 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Oral Health and Diseases)
Deep and subcortical white matter hyperintensity (DSWMH) lesions are a small-vessel disease of the brain. The aim of this cross-sectional study was to investigate the relationship between DSWMH lesions and periodontal status in Japanese adults who participated in a health check. We enrolled 444 consecutive participants (mean age, 54.5 years) who received both brain and oral health evaluation services at the Asahi University Hospital. Magnetic resonance imaging was used to detect DSWMH lesions. Periodontal status was assessed using the community periodontal index. Of the study participants, 215 (48.4%) had DSWMH lesions. Multivariate logistic regression showed that the presence of DSWMH lesions was significantly related to age ≥ 65 years (vs. < 65 years, odds ratio [OR] = 2.984, 95% confidence interval [CI] = 1.696–5.232), systolic blood pressure ≥ 140 mmHg (vs. < 140 mmHg, OR = 2.579, 95% CI = 1.252–5.314), the presence of ≥ 28 teeth (vs. < 28 teeth, OR = 0.635, 95% CI = 0.420–0.961), and probing pocket depth (PPD) ≥ 6 mm (vs. PPD < 6 mm, OR = 1.948, 95% CI = 1.132–3.354) after adjustment for confounding factors. Having PPD ≥ 6 mm may be a risk factor for DSWMH lesions in Japanese adults. View Full-Text
Keywords: periodontitis; brain; risk; cross-sectional study periodontitis; brain; risk; cross-sectional study
MDPI and ACS Style

Hada, M.; Azuma, T.; Irie, K.; Yonenaga, T.; Watanabe, K.; Deguchi, F.; Obora, A.; Kojima, T.; Tomofuji, T. Periodontal Condition Is Correlated with Deep and Subcortical White Matter Hyperintensity Lesions in Japanese Adults. Int. J. Environ. Res. Public Health 2020, 17, 1694. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17051694

AMA Style

Hada M, Azuma T, Irie K, Yonenaga T, Watanabe K, Deguchi F, Obora A, Kojima T, Tomofuji T. Periodontal Condition Is Correlated with Deep and Subcortical White Matter Hyperintensity Lesions in Japanese Adults. International Journal of Environmental Research and Public Health. 2020; 17(5):1694. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17051694

Chicago/Turabian Style

Hada, Minako, Tetsuji Azuma, Koichiro Irie, Takatoshi Yonenaga, Kazutoshi Watanabe, Fumiko Deguchi, Akihiro Obora, Takao Kojima, and Takaaki Tomofuji. 2020. "Periodontal Condition Is Correlated with Deep and Subcortical White Matter Hyperintensity Lesions in Japanese Adults" International Journal of Environmental Research and Public Health 17, no. 5: 1694. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17051694

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