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Article

Biological Monitoring of Occupational Exposure to Metals in Electric Steel Foundry Workers and Its Contribution to 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels

1
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2
Laboratory of Analysis, Treatment and Recovery of Environmental Pollutants and Products, Faculty of Pharmacy, 5000 Monastir, Tunisia
3
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(6), 1811; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17061811
Received: 31 January 2020 / Revised: 4 March 2020 / Accepted: 5 March 2020 / Published: 11 March 2020
(This article belongs to the Special Issue Human Biomonitoring of Environmental and Occupational Exposures)
In this study, the urinary concentrations of selected metals in workers from an electric steel foundry in Tunisia were assessed and compared with existing biological limit values and general population reference values. Moreover, the association between oxidative DNA damage, measured as urinary 8-oxo-7,8-dihydro-2’deoxyguanosine (8-oxodG) and co-exposure to metals and polycyclic aromatic hydrocarbons (PAHs) was evaluated. Urinary levels of 12 metals were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in end-shift spot samples from 89 workers. The urinary levels of phenanthrene (U-PHE), as marker of exposure to PAHs, and 8-oxodG were also available. Median levels ranged from 0.4 µg/L (cobalt, Co, and thallium, Tl) to 895 µg/L (zinc, Zn). Only 1% of samples was above the biological limit values for Co, and up to 13.5% of samples were above limit values for Cd. From 3.4% (Co) to 72% (lead, Pb) of samples were above the reference values for the general population. Multiple linear regression models, showed that manganese (Mn), Zn, arsenic (As), barium (Ba), Tl, and Pb were significant predictors of 8-oxodG (0.012 ≤ p ≤ 0.048); U-PHE was also a significant predictor (0.003 ≤ p ≤ 0.059). The variance explained by models was low (0.11 ≤ R2 ≤ 0.17, p < 0.005), showing that metals and PAHs were minor contributors to 8-oxodG. Overall, the comparison with biological limit values showed that the study subjects were occupationally exposed to metals, with levels exceeding biological limit values only for Cd. View Full-Text
Keywords: electric steel foundry; metals; urine; biological monitoring; occupational exposure; biological limit values; 8-oxo-7,8-dihydro-2′-deoxyguanosine; polycyclic aromatic hydrocarbons electric steel foundry; metals; urine; biological monitoring; occupational exposure; biological limit values; 8-oxo-7,8-dihydro-2′-deoxyguanosine; polycyclic aromatic hydrocarbons
MDPI and ACS Style

Campo, L.; Hanchi, M.; Sucato, S.; Consonni, D.; Polledri, E.; Olgiati, L.; Saidane-Mosbahi, D.; Fustinoni, S. Biological Monitoring of Occupational Exposure to Metals in Electric Steel Foundry Workers and Its Contribution to 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels. Int. J. Environ. Res. Public Health 2020, 17, 1811. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17061811

AMA Style

Campo L, Hanchi M, Sucato S, Consonni D, Polledri E, Olgiati L, Saidane-Mosbahi D, Fustinoni S. Biological Monitoring of Occupational Exposure to Metals in Electric Steel Foundry Workers and Its Contribution to 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels. International Journal of Environmental Research and Public Health. 2020; 17(6):1811. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17061811

Chicago/Turabian Style

Campo, Laura, Mariem Hanchi, Sabrina Sucato, Dario Consonni, Elisa Polledri, Luca Olgiati, Dalila Saidane-Mosbahi, and Silvia Fustinoni. 2020. "Biological Monitoring of Occupational Exposure to Metals in Electric Steel Foundry Workers and Its Contribution to 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels" International Journal of Environmental Research and Public Health 17, no. 6: 1811. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17061811

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