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Review

Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

1
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
2
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, La Sapienza University of Rome, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(7), 2580; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17072580
Received: 11 March 2020 / Revised: 5 April 2020 / Accepted: 7 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Women’s Health: Molecular and Morphological Perspectives)
Mancozeb is a widely used fungicide approved for use in agriculture in many countries with long persistence in the environment and consequent bioaccumulation in tissues and biological fluids. Despite the large amount of studies published in recent years, the relationship between mancozeb exposure and female reproductive health is not fully elucidated. In order to summarize current evidence on mancozeb exposure and female reproductive disease, we performed a systematic review of literature. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to make this review. An adapted version of the National Toxicology Program’s Office of Health and Assessment and Translation (OHAT) framework was used to evaluate the risk of bias. Electronic search on two databases (PubMed and Scopus) was used to find experimental studies (in vitro and in vivo) on mancozeb exposure. The database search identified 250 scientific articles, 20 of which met our inclusion criteria. Selected data were then reviewed and summarized in tables. Overall, mancozeb represents a hazard for female reproductive health, with different mechanisms of action. Undoubtedly more experimental and epidemiological studies are required to definitively validate mancozeb as reproductive toxicant. View Full-Text
Keywords: mancozeb; female reproduction; fertility; systematic review mancozeb; female reproduction; fertility; systematic review
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MDPI and ACS Style

Bianchi, S.; Nottola, S.A.; Torge, D.; Palmerini, M.G.; Necozione, S.; Macchiarelli, G. Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models. Int. J. Environ. Res. Public Health 2020, 17, 2580. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17072580

AMA Style

Bianchi S, Nottola SA, Torge D, Palmerini MG, Necozione S, Macchiarelli G. Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models. International Journal of Environmental Research and Public Health. 2020; 17(7):2580. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17072580

Chicago/Turabian Style

Bianchi, Serena, Stefania A. Nottola, Diana Torge, Maria G. Palmerini, Stefano Necozione, and Guido Macchiarelli. 2020. "Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models" International Journal of Environmental Research and Public Health 17, no. 7: 2580. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17072580

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