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Review

The Effects of Pharmacological and Non-Pharmacological Interventions on Symptom Management and Quality of Life among Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy: A Systematic Review

1
The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
2
Department of Psychology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada
3
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(8), 2950; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082950
Received: 19 March 2020 / Revised: 17 April 2020 / Accepted: 18 April 2020 / Published: 24 April 2020
Breast cancer survivors need to undergo adjuvant endocrine therapy after completion of curative treatments to prevent disease recurrence. These individuals often experience symptoms which are detrimental to their quality of life (QOL). Implementation of interventions for effective symptom management among these survivors is warranted. This review provides an overview of studies on the effectiveness of the previously developed interventions for breast cancer survivors undergoing adjuvant endocrine therapy on symptom alleviation and enhancement of QOL or health-related QOL (HRQOL). Five electronic databases were employed in the literature search. Study selection, data extraction and critical appraisal of the included studies were conducted by three authors independently. Twenty-four studies were included. Both pharmacological and non-pharmacological interventions are effective in addressing the symptoms associated with adjuvant endocrine therapy among the breast cancer survivors, and in improving their QOL, although discrepancies were noted between the studies in terms of the significance of these effects. Pharmacological and non-pharmacological interventions can be effective for symptom management among breast cancer survivors. Their implementation is recommended for effective survivorship care for these individuals. Further research on intervention development for breast cancer survivors is recommended to provide further evidence for the utility of the explored interventions in survivorship care for these patients. View Full-Text
Keywords: Breast cancer; endocrine therapy; hormonal therapy; intervention; quality of life; symptom; survivorship care Breast cancer; endocrine therapy; hormonal therapy; intervention; quality of life; symptom; survivorship care
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MDPI and ACS Style

Chan, C.W.H.; Tai, D.; Kwong, S.; Chow, K.M.; Chan, D.N.S.; Law, B.M.H. The Effects of Pharmacological and Non-Pharmacological Interventions on Symptom Management and Quality of Life among Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy: A Systematic Review. Int. J. Environ. Res. Public Health 2020, 17, 2950. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082950

AMA Style

Chan CWH, Tai D, Kwong S, Chow KM, Chan DNS, Law BMH. The Effects of Pharmacological and Non-Pharmacological Interventions on Symptom Management and Quality of Life among Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy: A Systematic Review. International Journal of Environmental Research and Public Health. 2020; 17(8):2950. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082950

Chicago/Turabian Style

Chan, Carmen W.H., Daria Tai, Stephanie Kwong, Ka M. Chow, Dorothy N.S. Chan, and Bernard M.H. Law 2020. "The Effects of Pharmacological and Non-Pharmacological Interventions on Symptom Management and Quality of Life among Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy: A Systematic Review" International Journal of Environmental Research and Public Health 17, no. 8: 2950. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082950

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