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Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent
Article

The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon

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Department of Molecular Biology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
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Department of Athletics, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
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Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, 81-519 Gdynia, Poland
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Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-11 Szczecin, Poland
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Department of Biochemistry, Institute of Sport, National Research Institute, 01-982 Warsaw, Poland
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Faculty of Physical Education, Jozef Piłsudski University of Physical Education in Warsaw, 01-813 Warsaw, Poland
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Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
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Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland
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Exercise Physiology Laboratory, 18450 Nikaia, Greece
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Medbase St. Gallen Am Vadianplatz, 9001 St. Gallen, Switzerland
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(8), 2962; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082962
Received: 29 March 2020 / Revised: 20 April 2020 / Accepted: 21 April 2020 / Published: 24 April 2020
Deficiencies in iron and vitamin D are frequently observed in athletes. Therefore, we examined whether different baseline vitamin D3 levels have any impact on post-exercise serum hepcidin, IL-6 and iron responses in ultra-marathon runners. In this randomized control trial, the subjects (20 male, amateur runners, mean age 40.75 ± 7.15 years) were divided into two groups: experimental (VD) and control (CON). The VD group received vitamin D3 (10,000 UI/day) and the CON group received a placebo for two weeks before the run. Venous blood samples were collected on three occasions—before the run, after the 100 km ultra-marathon and 12 h after the run—to measure iron metabolism indicators, hepcidin, and IL-6 concentration. After two weeks of supplementation, the intervention group demonstrated a higher level of serum 25(OH)D than the CON group (27.82 ± 5.8 ng/mL vs. 20.41 ± 4.67 ng/mL; p < 0.05). There were no differences between the groups before and after the run in the circulating hepcidin and IL-6 levels. The decrease in iron concentration immediately after the 100-km ultra-marathon was smaller in the VD group than CON (p < 0.05). These data show that various vitamin D3 status can affect the post-exercise metabolism of serum iron. View Full-Text
Keywords: ultra-endurance; metabolism; nutrition; iron deficiency ultra-endurance; metabolism; nutrition; iron deficiency
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MDPI and ACS Style

Kasprowicz, K.; Ratkowski, W.; Wołyniec, W.; Kaczmarczyk, M.; Witek, K.; Żmijewski, P.; Renke, M.; Jastrzębski, Z.; Rosemann, T.; Nikolaidis, P.T.; Knechtle, B. The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon. Int. J. Environ. Res. Public Health 2020, 17, 2962. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082962

AMA Style

Kasprowicz K, Ratkowski W, Wołyniec W, Kaczmarczyk M, Witek K, Żmijewski P, Renke M, Jastrzębski Z, Rosemann T, Nikolaidis PT, Knechtle B. The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon. International Journal of Environmental Research and Public Health. 2020; 17(8):2962. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082962

Chicago/Turabian Style

Kasprowicz, Katarzyna, Wojciech Ratkowski, Wojciech Wołyniec, Mariusz Kaczmarczyk, Konrad Witek, Piotr Żmijewski, Marcin Renke, Zbigniew Jastrzębski, Thomas Rosemann, Pantelis T. Nikolaidis, and Beat Knechtle. 2020. "The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon" International Journal of Environmental Research and Public Health 17, no. 8: 2962. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082962

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