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Article

Treatment Patterns and Pharmacoutilization in Patients Affected by Rheumatoid Arthritis in Italian Settings

1
CliCon S.r.l., Health Economics and Outcomes Research, 40141 Bologna, Italy
2
Eli Lilly Italy S.p.A., 50019 Sesto Fiorentino, Italy
3
Eli Lilly and Company Limited, Windlesham GU20 6PH, UK
4
Eli Lilly Italy S.p.A., 00144 Roma, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Matteo Franchi, Anna Cantarutti, Federico Rea and Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(11), 5679; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115679
Received: 28 April 2021 / Revised: 20 May 2021 / Accepted: 23 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Real-World Evidence in Clinical Epidemiology and Public Health)
This study aimed to evaluate the treatment patterns and pharmacoutilization of patients with rheumatoid arthritis (RA) in real-world settings in Italy. This retrospective observational analysis was based on administrative databases of selected Italian entities. All adult patients with RA diagnosis confirmed by ≥1 discharge diagnosis of RA (ICD-9-CM code = 714.0) or an active exemption code (006.714.0) were enrolled in 2019. Two cohorts were created: one included patients prescribed baricitinib, the other those prescribed biological disease-modifying antirheumatic drugs (bDMARDs). Overall, 47,711 RA patients were identified, most of them without DMARD prescription. As a first-line prescription, 43.2% of patients were prescribed conventional synthetic DMARDs (csDMARDs), 5.2% bDMARDs and 0.3% baricitinib. In 2019, 82.6% of csDMARD users continued with the same DMARD category, 15.9% had a bDMARD, while 1.5% had baricitinib as second-line therapy. Overall, 445 patients used baricitinib during 2019. During follow-up, baricitinib was prescribed as monotherapy to 31% of patients, as cotreatment with csDMARDs and corticosteroids to 27% of patients, with corticosteroids to 28% of patients and with csDMARDs to 14% of patients. In line with previous findings, a trend of bDMARD undertreatment was observed. The treatment patterns of baricitinib patients could help to better characterize patients eligible for new therapeutic options that will be available in the future. View Full-Text
Keywords: biologic drugs; baricitinib; Janus kinase inhibitors; rheumatoid arthritis biologic drugs; baricitinib; Janus kinase inhibitors; rheumatoid arthritis
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MDPI and ACS Style

Perrone, V.; Losi, S.; Rogai, V.; Antonelli, S.; Fakhouri, W.; Giovannitti, M.; Giacomini, E.; Sangiorgi, D.; Degli Esposti, L. Treatment Patterns and Pharmacoutilization in Patients Affected by Rheumatoid Arthritis in Italian Settings. Int. J. Environ. Res. Public Health 2021, 18, 5679. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115679

AMA Style

Perrone V, Losi S, Rogai V, Antonelli S, Fakhouri W, Giovannitti M, Giacomini E, Sangiorgi D, Degli Esposti L. Treatment Patterns and Pharmacoutilization in Patients Affected by Rheumatoid Arthritis in Italian Settings. International Journal of Environmental Research and Public Health. 2021; 18(11):5679. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115679

Chicago/Turabian Style

Perrone, Valentina, Serena Losi, Veronica Rogai, Silvia Antonelli, Walid Fakhouri, Massimo Giovannitti, Elisa Giacomini, Diego Sangiorgi, and Luca Degli Esposti. 2021. "Treatment Patterns and Pharmacoutilization in Patients Affected by Rheumatoid Arthritis in Italian Settings" International Journal of Environmental Research and Public Health 18, no. 11: 5679. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115679

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