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Article

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

1
Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
2
Department of Public Health, College of Public Health, China Medical University, Taichung City 406040, Taiwan
3
Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo 143-8540, Japan
*
Author to whom correspondence should be addressed.
Membership of the Japan Environment and Children’s Study Group is provided in the Acknowledgements.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(11), 5929; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115929
Received: 7 May 2021 / Revised: 26 May 2021 / Accepted: 27 May 2021 / Published: 31 May 2021
Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10. View Full-Text
Keywords: organophosphate pesticides; dialkylphosphates; urine; biomarker; pregnant women; birth cohort; cumulative risk assessment; relative potency factors organophosphate pesticides; dialkylphosphates; urine; biomarker; pregnant women; birth cohort; cumulative risk assessment; relative potency factors
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MDPI and ACS Style

Nishihama, Y.; Nakayama, S.F.; Isobe, T.; Jung, C.-R.; Iwai-Shimada, M.; Kobayashi, Y.; Michikawa, T.; Sekiyama, M.; Taniguchi, Y.; Yamazaki, S.; on behalf of the Japan Environment and Children’s Study Group. Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS). Int. J. Environ. Res. Public Health 2021, 18, 5929. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115929

AMA Style

Nishihama Y, Nakayama SF, Isobe T, Jung C-R, Iwai-Shimada M, Kobayashi Y, Michikawa T, Sekiyama M, Taniguchi Y, Yamazaki S, on behalf of the Japan Environment and Children’s Study Group. Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS). International Journal of Environmental Research and Public Health. 2021; 18(11):5929. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115929

Chicago/Turabian Style

Nishihama, Yukiko, Shoji F. Nakayama, Tomohiko Isobe, Chau-Ren Jung, Miyuki Iwai-Shimada, Yayoi Kobayashi, Takehiro Michikawa, Makiko Sekiyama, Yu Taniguchi, Shin Yamazaki, and on behalf of the Japan Environment and Children’s Study Group. 2021. "Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)" International Journal of Environmental Research and Public Health 18, no. 11: 5929. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115929

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