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Article

The Effect of Bilateral Nephrectomy on Renalase and Catecholamines in Hemodialysis Patients

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Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
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Immunology and Laboratory Medicine, Department of Microbiology, Pomeranian Medical University, 70-111 Szczecin, Poland
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Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
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Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland
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Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Luis D’ Marco
Int. J. Environ. Res. Public Health 2021, 18(12), 6282; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18126282
Received: 6 May 2021 / Revised: 2 June 2021 / Accepted: 8 June 2021 / Published: 10 June 2021
(This article belongs to the Special Issue Chronic Kidney Disease: The Global Challenge)
Background/Aims: Renalase is an enzyme with monoamine oxidase activity that metabolizes catecholamines; therefore, it has a significant influence on arterial blood pressure regulation and the development of cardiovascular diseases. Renalase is mainly produced in the kidneys. Nephrectomy and hemodialysis (HD) may alter the production and metabolism of renalase. The aim of this study was to examine the effect of bilateral nephrectomy on renalase levels in the serum and erythrocytes of hemodialysis patients. Methods: This study included 27 hemodialysis patients post-bilateral nephrectomy, 46 hemodialysis patients without nephrectomy but with chronic kidney disease and anuria and 30 healthy subjects with normal kidney function. Renalase levels in the serum and erythrocytes were measured using an ELISA kit. Results: Serum concentrations of renalase were significantly higher in post-bilateral nephrectomy patients when compared with those of control subjects (101.1 ± 65.5 vs. 19.6 ± 5.0; p < 0.01). Additionally, renalase concentrations, calculated per gram of hemoglobin, were significantly higher in patients after bilateral nephrectomy in comparison with those of healthy subjects (994.9 ± 345.5 vs. 697.6 ± 273.4, p = 0.015). There were no statistically significant differences in plasma concentrations of noradrenaline or adrenaline. In contrast, the concentration of dopamine was significantly lower in post-nephrectomy patients when compared with those of healthy subjects (116.8 ± 147.7 vs. 440.9 ± 343.2, p < 0.01). Conclusions: Increased serum levels of renalase in post-bilateral nephrectomy hemodialysis patients are likely related to production in extra-renal organs as a result of changes in the cardiovascular system and hypertension. View Full-Text
Keywords: renalase; kidney; erythrocytes; bilateral nephrectomy; chronic kidney disease renalase; kidney; erythrocytes; bilateral nephrectomy; chronic kidney disease
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MDPI and ACS Style

Wiśniewska, M.; Serwin, N.; Dziedziejko, V.; Marchelek-Myśliwiec, M.; Dołęgowska, B.; Domański, L.; Ciechanowski, K.; Safranow, K.; Gołębiowski, T.; Pawlik, A. The Effect of Bilateral Nephrectomy on Renalase and Catecholamines in Hemodialysis Patients. Int. J. Environ. Res. Public Health 2021, 18, 6282. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18126282

AMA Style

Wiśniewska M, Serwin N, Dziedziejko V, Marchelek-Myśliwiec M, Dołęgowska B, Domański L, Ciechanowski K, Safranow K, Gołębiowski T, Pawlik A. The Effect of Bilateral Nephrectomy on Renalase and Catecholamines in Hemodialysis Patients. International Journal of Environmental Research and Public Health. 2021; 18(12):6282. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18126282

Chicago/Turabian Style

Wiśniewska, Magda, Natalia Serwin, Violetta Dziedziejko, Małgorzata Marchelek-Myśliwiec, Barbara Dołęgowska, Leszek Domański, Kazimierz Ciechanowski, Krzysztof Safranow, Tomasz Gołębiowski, and Andrzej Pawlik. 2021. "The Effect of Bilateral Nephrectomy on Renalase and Catecholamines in Hemodialysis Patients" International Journal of Environmental Research and Public Health 18, no. 12: 6282. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18126282

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