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Article

The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects

1
Graduate School of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Johnann-ku, Fukuoka 814-0180, Japan
2
Faculty of Fukuoka Medical Technology, Teikyo University, 6-22 Misakimachi, Omuta, Fukuoka 836-8505, Japan
3
Laboratory of Exercise Physiology, Faculty of Sports of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
4
The Fukuoka University Institute for Physical Activity, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
5
Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0133, Japan
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Fukuoka University Health Care Center, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0133, Japan
7
Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0133, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Bruno Ramos-Molina, Fernando Cardona and Maria Del Ben
Int. J. Environ. Res. Public Health 2021, 18(13), 6980; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18136980
Received: 2 May 2021 / Revised: 22 June 2021 / Accepted: 23 June 2021 / Published: 29 June 2021
Liver fibrosis might be linked to the prevalence of chronic kidney disease (CKD). However, there is little information about the association between liver fibrosis and decreased kidney function in middle-aged and older subjects. We aimed to evaluate the influence of liver fibrosis on the incidence or prevalence of CKD stage 3–5 in a retrospective cross-sectional study (Study 1, n = 806) and a 6-year longitudinal study (Study 2, n = 380) of middle-aged and older subjects. We evaluated liver fibrosis using the Fibrosis-4 (FIB-4) index and kidney function using the estimated glomerular filtration rate (eGFR) of all subjects. All subjects were divided into four groups on the basis of their FIB-4 score quartiles (low to high). In the Jonckheere–Terpstra trend test of Study 1, the eGFR decreased significantly from the lowest group to the highest group (p < 0.001). The Kaplan–Meier survival curve in Study 2 showed that the cumulative prevalence of CKD stage 3–5 was higher in the third quartile than the other quartiles. Our results suggest that liver fibrosis could be a useful indicator for the prevalence of CKD, even within a relatively healthy population, although liver fibrosis was not an independent risk factor. View Full-Text
Keywords: liver fibrosis; decreased kidney function; CKD; FIB-4 index liver fibrosis; decreased kidney function; CKD; FIB-4 index
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MDPI and ACS Style

Kotoku, K.; Michishita, R.; Matsuda, T.; Kawakami, S.; Morito, N.; Uehara, Y.; Higaki, Y. The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects. Int. J. Environ. Res. Public Health 2021, 18, 6980. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18136980

AMA Style

Kotoku K, Michishita R, Matsuda T, Kawakami S, Morito N, Uehara Y, Higaki Y. The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects. International Journal of Environmental Research and Public Health. 2021; 18(13):6980. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18136980

Chicago/Turabian Style

Kotoku, Kazuko, Ryoma Michishita, Takuro Matsuda, Shotaro Kawakami, Natsumi Morito, Yoshinari Uehara, and Yasuki Higaki. 2021. "The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects" International Journal of Environmental Research and Public Health 18, no. 13: 6980. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18136980

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