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Review

Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review

1
Laboratory P2S (Health Systemic Process), UR4129, University Claude Bernard of Lyon 1, University of Lyon, Lyon, France
2
Public Health Laboratory (LASAP), ED2S Doctoral School of Sciences and Health, University Joseph Ki Zerbo, Ouagadougou 7021, Burkina Faso
3
Public Health Service, Department of Dentistry, Faculty of Medicine, Pharmacy and Dentistry, University Cheikh Anta Diop, Dakar 10700, Senegal
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(13), 7194; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18137194
Received: 5 June 2021 / Revised: 1 July 2021 / Accepted: 3 July 2021 / Published: 5 July 2021
(This article belongs to the Special Issue Oral Microbiota and Oral Health)
Background: Pre-eclampsia, the second most frequent direct source of maternal mortality, is a multisystem gestational disorder characterized by proteinuria and maternal hypertension after the 20th gestational week. Although the causes of pre-eclampsia are still discussed, research has suggested that the placenta has a central place in the pathogenesis of this disease. Moreover, current surveys indicated that periodontal disorders observed during the pregnancy and more particularly, periodontal pathogens could be link to the risk of pre-eclampsia. Objectives: This article aims to review recent studies focusing on periodontal conditions and pathogens associated with pre-eclampsia. Methods: The process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Results: Metabolic conditions, immunological changes, fluctuating progesterone and estrogen levels of the pregnant woman induce a dysbiosis of the oral microbiota and contribute to increase inflammation of periodontal tissues. Periodontal pathogens could diffuse through the bloodstream inducing a placenta inflammatory response as well as inflammatory molecules produced in response to periodontopathogens could migrate through the bloodstream leading to a placenta inflammatory response. Also, periodontopathogens can colonize the vaginal microbiota through the gastrointestinal tract or during oro-genital contacts. Conclusion: A cumulative bi-directional relationship between periodontal conditions, pathogens and the pre-eclampsia exists. View Full-Text
Keywords: periodontal disease; oral microbiota; periodontal pathogens; pre-eclampsia; gingivitis; pregnancy; dysbiosis; placenta; inflammation periodontal disease; oral microbiota; periodontal pathogens; pre-eclampsia; gingivitis; pregnancy; dysbiosis; placenta; inflammation
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MDPI and ACS Style

Gare, J.; Kanoute, A.; Meda, N.; Viennot, S.; Bourgeois, D.; Carrouel, F. Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review. Int. J. Environ. Res. Public Health 2021, 18, 7194. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18137194

AMA Style

Gare J, Kanoute A, Meda N, Viennot S, Bourgeois D, Carrouel F. Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review. International Journal of Environmental Research and Public Health. 2021; 18(13):7194. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18137194

Chicago/Turabian Style

Gare, Jocelyne, Aida Kanoute, Nicolas Meda, Stephane Viennot, Denis Bourgeois, and Florence Carrouel. 2021. "Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review" International Journal of Environmental Research and Public Health 18, no. 13: 7194. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18137194

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