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Advanced Glycation End Products: New Clinical and Molecular Perspectives

1
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
2
Faculty of Medicine, School of Medicine, University of Buenos Aires, Buenos Aires 1121, Argentina
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Faculty of Medicine, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
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City of Houston Health Department, Houston, TX 77054, USA
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Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andrés Bello, Sede Concepción 4260000, Chile
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Facultad de Medicina, Universidad Católica de Cuenca, Cuenca 010105, Ecuador
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Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia
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Department of Nephrology, Hospital Clinico Universitario de Valencia, INCLIVA, University of Valencia, 46010 Valencia, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: José Carmelo Adsuar Sala
Int. J. Environ. Res. Public Health 2021, 18(14), 7236; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147236
Received: 2 June 2021 / Revised: 30 June 2021 / Accepted: 3 July 2021 / Published: 6 July 2021
(This article belongs to the Special Issue Chronic Kidney Disease: The Global Challenge)
Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF). Hence, this study aimed to establish an update about the molecular mechanisms induced by AGEs during the evolution of chronic complications of DM and describe the newer measurement techniques available, highlighting SAF as a possible tool to measure the risk of developing DM chronic complications. View Full-Text
Keywords: advanced glycation end products; diabetes mellitus; chronic complications; skin fluorescence advanced glycation end products; diabetes mellitus; chronic complications; skin fluorescence
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MDPI and ACS Style

Salazar, J.; Navarro, C.; Ortega, Á.; Nava, M.; Morillo, D.; Torres, W.; Hernández, M.; Cabrera, M.; Angarita, L.; Ortiz, R.; Chacín, M.; D’Marco, L.; Bermúdez, V. Advanced Glycation End Products: New Clinical and Molecular Perspectives. Int. J. Environ. Res. Public Health 2021, 18, 7236. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147236

AMA Style

Salazar J, Navarro C, Ortega Á, Nava M, Morillo D, Torres W, Hernández M, Cabrera M, Angarita L, Ortiz R, Chacín M, D’Marco L, Bermúdez V. Advanced Glycation End Products: New Clinical and Molecular Perspectives. International Journal of Environmental Research and Public Health. 2021; 18(14):7236. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147236

Chicago/Turabian Style

Salazar, Juan, Carla Navarro, Ángel Ortega, Manuel Nava, Daniela Morillo, Wheeler Torres, Marlon Hernández, Mayela Cabrera, Lissé Angarita, Rina Ortiz, Maricarmen Chacín, Luis D’Marco, and Valmore Bermúdez. 2021. "Advanced Glycation End Products: New Clinical and Molecular Perspectives" International Journal of Environmental Research and Public Health 18, no. 14: 7236. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147236

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