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Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis

1
Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
2
Epidemiological Department, Azienda Zero Regione del Veneto, via Jacopo Avanzo 35, 35132 Padova, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Myriam Khlat
Int. J. Environ. Res. Public Health 2021, 18(14), 7249; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147249
Received: 12 May 2021 / Revised: 30 June 2021 / Accepted: 1 July 2021 / Published: 6 July 2021
Mortality from idiopathic pulmonary fibrosis (IPF) is increasing in most European countries, but there are no data for Italy. We analysed the registry data from a region in northeastern Italy to assess the trends in IPF-related mortality during 2008–2019, to compare results of underlying vs. multiple cause of death analyses, and to describe the impact of the COVID-19 epidemic in 2020. We identified IPF (ICD-10 code J84.1) among the causes of death registered in 557,932 certificates in the Veneto region. We assessed time trends in annual age-standardized mortality rates by gender and age (40–74, 75–84, and ≥85 years). IPF was the underlying cause of 1310 deaths in the 2251 certificates mentioning IPF. For all age groups combined, the age-standardized mortality rate from IPF identified as the underlying cause of death was close to the European median (males and females: 3.1 and 1.3 per 100,000/year, respectively). During 2008–2019, mortality rates increased in men aged ≥85 years (annual percent change of 6.5%, 95% CI: 2.0, 11.2%), but not among women or for the younger age groups. A 72% excess of IPF-related deaths was registered in March–April 2020 (mortality ratio 1.72, 95% CI: 1.29, 2.24). IPF mortality was increasing among older men in northeastern Italy. The burden of IPF was heavier than assessed by routine statistics, since less than two out of three IPF-related deaths were directly attributed to this condition. COVID-19 was accompanied by a remarkable increase in IPF-related mortality. View Full-Text
Keywords: idiopathic pulmonary fibrosis; mortality; time trends analysis; multiple cause of death; underlying cause of death; COVID-19; epidemiology idiopathic pulmonary fibrosis; mortality; time trends analysis; multiple cause of death; underlying cause of death; COVID-19; epidemiology
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MDPI and ACS Style

Marcon, A.; Schievano, E.; Fedeli, U. Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis. Int. J. Environ. Res. Public Health 2021, 18, 7249. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147249

AMA Style

Marcon A, Schievano E, Fedeli U. Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis. International Journal of Environmental Research and Public Health. 2021; 18(14):7249. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147249

Chicago/Turabian Style

Marcon, Alessandro, Elena Schievano, and Ugo Fedeli. 2021. "Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis" International Journal of Environmental Research and Public Health 18, no. 14: 7249. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147249

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