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Article

The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border

1
Department of Biological Sciences, College of Science, The University of Texas at El Paso, El Paso, TX 79968, USA
2
Department of Mathematical Sciences, College of Science, The University of Texas at El Paso, El Paso, TX 79968, USA
3
Department of Biochemistry, Cancer Biology Division, Ponce Research Institute, Ponce Health Sciences University, Ponce, PR 00716, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Paul B. Tchounwou, Daniel F. Sarpong, Elizabeth O. Ofili, Emma Fernandez-Repollet, Richard J. Noel, Magda Shaheen, Kristen J. Wells and Richard Yanagihara
Int. J. Environ. Res. Public Health 2021, 18(14), 7345; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147345
Received: 1 April 2021 / Revised: 12 June 2021 / Accepted: 6 July 2021 / Published: 9 July 2021
Next-generation sequencing (NGS) has identified unique biomarkers yielding new strategies in precision medicine for the treatment of Acute lymphoblastic leukemia (ALL). Hispanics show marked health disparities in ALL, often absent in clinical trials or cancer research. Thus, it is unknown whether Hispanics would benefit equally from curated data currently guiding precision oncology. Using whole-exome sequencing, nine ALL patients were screened for mutations within genes known to possess diagnostic, prognostic and therapeutic value. Genes mutated in Hispanic ALL patients from the borderland were mined for potentially pathogenic variants within clinically relevant genes. KRAS G12A was detected in this unique cohort and its frequency in Hispanics from the TARGET-ALL Phase II database was three-fold greater than that of non-Hispanics. STAT5B N642H was also detected with low frequency in Hispanic and non-Hispanic individuals within TARGET. Its detection within this small cohort may reflect a common event in this demographic. Such variants occurring in the MAPK and JAK/STAT pathways may be contributing to Hispanic health disparities in ALL. Notable variants in ROS1, WT1, and NOTCH2 were observed in the ALL borderland cohort, with NOTCH2 C19W occurring most frequently. Further investigations on the pathogenicity of these variants are needed to assess their relevance in ALL. View Full-Text
Keywords: ALL; relapse; precision medicine; Hispanic health disparities; KRAS; STAT5B; NOTCH2; ROS1; WT1 ALL; relapse; precision medicine; Hispanic health disparities; KRAS; STAT5B; NOTCH2; ROS1; WT1
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MDPI and ACS Style

Grant, A.H.; Ayala-Marin, Y.M.; Mohl, J.E.; Robles-Escajeda, E.; Rodriguez, G.; Dutil, J.; Kirken, R.A. The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border. Int. J. Environ. Res. Public Health 2021, 18, 7345. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147345

AMA Style

Grant AH, Ayala-Marin YM, Mohl JE, Robles-Escajeda E, Rodriguez G, Dutil J, Kirken RA. The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border. International Journal of Environmental Research and Public Health. 2021; 18(14):7345. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147345

Chicago/Turabian Style

Grant, Alice H., Yoshira M. Ayala-Marin, Jonathon E. Mohl, Elisa Robles-Escajeda, Georgialina Rodriguez, Julie Dutil, and Robert A. Kirken 2021. "The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border" International Journal of Environmental Research and Public Health 18, no. 14: 7345. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18147345

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