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Are the Effects of DES Over? A Tragic Lesson from the Past

Department of Preclinical Sciences, Faculty of Medicine, Universidad Católica del Maule, Talca 3460000, Chile
Academic Editor: Yukiko Washio
Int. J. Environ. Res. Public Health 2021, 18(19), 10309; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph181910309
Received: 2 August 2021 / Revised: 23 September 2021 / Accepted: 24 September 2021 / Published: 30 September 2021
Diethylstilbestrol (DES), a transplacental endocrine-disrupting chemical, was prescribed to pregnant women for several decades. The number of women who took DES is hard to know precisely, but it has been estimated that over 10 million people have been exposed around the world. DES was classified in the year 2000 as carcinogenic to humans. The deleterious effects induced by DES are very extensive, such as abnormalities or cancers of the genital tract and breast, neurodevelopmental alterations, problems associated with socio-sexual behavior, and immune, pancreatic and cardiovascular disorders. Not only pregnant women but also their children and grandchildren have been affected. Epigenetic alterations have been detected, and intergenerational effects have been observed. More cohort follow-up studies are needed to establish if DES effects are transgenerational. Even though DES is not currently in use, its effects are still present, and families previously exposed and their later generations deserve the continuity of the research studies. View Full-Text
Keywords: diethylstilbestrol; DES; endocrine-disrupting chemical; pregnancy; offspring outcomes diethylstilbestrol; DES; endocrine-disrupting chemical; pregnancy; offspring outcomes
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MDPI and ACS Style

Zamora-León, P. Are the Effects of DES Over? A Tragic Lesson from the Past. Int. J. Environ. Res. Public Health 2021, 18, 10309. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph181910309

AMA Style

Zamora-León P. Are the Effects of DES Over? A Tragic Lesson from the Past. International Journal of Environmental Research and Public Health. 2021; 18(19):10309. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph181910309

Chicago/Turabian Style

Zamora-León, Pilar. 2021. "Are the Effects of DES Over? A Tragic Lesson from the Past" International Journal of Environmental Research and Public Health 18, no. 19: 10309. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph181910309

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