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Article

Anhedonia as a Potential Risk Factor of Alzheimer’s Disease in a Community-Dwelling Elderly Sample: Results from the ZARADEMP Project

1
Psychiatry Service, Hospital Clínico Universitario Lozano Blesa, 50009 Zaragoza, Spain
2
Department of Medicine, Psychiatry and Dermatology, Universidad de Zaragoza, 50009 Zaragoza, Spain
3
Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain
4
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, 28029 Madrid, Spain
5
Research, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, 08007 Barcelona, Spain
6
Psychiatry Service, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
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Department of Psychology and Sociology, Universidad de Zaragoza, 50009 Zaragoza, Spain
8
Department of Microbiology, Pediatrics, Radiology and Public Health, Universidad de Zaragoza, 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
Both authors contributed equally.
Academic Editor: Maryam Vasefi
Int. J. Environ. Res. Public Health 2021, 18(4), 1370; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18041370
Received: 18 December 2020 / Revised: 22 January 2021 / Accepted: 30 January 2021 / Published: 3 February 2021
(This article belongs to the Special Issue Risk Factors for Dementia and Alzheimer's Disease)
(1) Introduction: Dementia is a major public health problem, and Alzheimer’s disease (AD) is the most frequent subtype. Clarifying the potential risk factors is necessary in order to improve dementia-prevention strategies and quality of life. Here, our purpose was to investigate the role of the absence of hedonic tone; anhedonia, understood as the reduction on previous enjoyable daily activities, which occasionally is underdetected and underdiagnosed; and the risk of developing AD in a cognitively unimpaired and non-depressed population sample. (2) Method: We used data from the Zaragoza Dementia and Depression (ZARADEMP) project, a longitudinal epidemiological study on dementia and depression. After excluding subjects with dementia, a sample of 2830 dwellers aged ≥65 years was followed for 4.5 years. The geriatric mental state examination was used to identify cases of anhedonia. AD was diagnosed by a panel of research psychiatrists according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. A multivariate survival analysis and Cox proportional hazards regression model were performed, and the analysis was controlled by an analysis for the presence of clinically significant depression. (3) Results: We found a significant association between anhedonia cases and AD risk in the univariate analysis (hazard ratio (HR): 2.37; 95% CI: 1.04–5.40). This association persisted more strongly in the fully adjusted model. (4) Conclusions: Identifying cognitively intact individuals with anhedonia is a priority to implement preventive strategies that could delay the progression of cognitive and functional impairment in subjects at risk of AD. View Full-Text
Keywords: anhedonia; Alzheimer’s disease; psychopathology; risk factor; neuropsychiatry; community study anhedonia; Alzheimer’s disease; psychopathology; risk factor; neuropsychiatry; community study
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MDPI and ACS Style

Vaquero-Puyuelo, D.; De-la-Cámara, C.; Olaya, B.; Gracia-García, P.; Lobo, A.; López-Antón, R.; Santabárbara, J. Anhedonia as a Potential Risk Factor of Alzheimer’s Disease in a Community-Dwelling Elderly Sample: Results from the ZARADEMP Project. Int. J. Environ. Res. Public Health 2021, 18, 1370. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18041370

AMA Style

Vaquero-Puyuelo D, De-la-Cámara C, Olaya B, Gracia-García P, Lobo A, López-Antón R, Santabárbara J. Anhedonia as a Potential Risk Factor of Alzheimer’s Disease in a Community-Dwelling Elderly Sample: Results from the ZARADEMP Project. International Journal of Environmental Research and Public Health. 2021; 18(4):1370. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18041370

Chicago/Turabian Style

Vaquero-Puyuelo, David, Concepción De-la-Cámara, Beatriz Olaya, Patricia Gracia-García, Antonio Lobo, Raúl López-Antón, and Javier Santabárbara. 2021. "Anhedonia as a Potential Risk Factor of Alzheimer’s Disease in a Community-Dwelling Elderly Sample: Results from the ZARADEMP Project" International Journal of Environmental Research and Public Health 18, no. 4: 1370. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18041370

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