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Article

Association of CX3CR1 Gene Polymorphisms with Fractalkine, Fractalkine Receptor, and C-Reactive Protein Levels in Patients with Kidney Failure

Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
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Academic Editor: Juan González Ruiz
Int. J. Environ. Res. Public Health 2021, 18(4), 2202; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18042202
Received: 12 January 2021 / Revised: 17 February 2021 / Accepted: 19 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Obesity, Diabetes and Chronic Kidney Disease)
Fractalkine (CX3CL1) is a chemokine that plays a significant role in inflammation, one of the pathophysiological processes underlying end-stage renal disease (ESRD). Genetic factors are significantly involved in cytokine expression and have been studied as potential risk factors for chronic kidney disease (CKD). Objectives: We aimed to elucidate the association of CX3CR1 gene polymorphisms rs3732378 and rs3732379 with the levels of CX3CL1, CX3CL1 receptor (CX3CR1), as well as C-reactive protein (CRP). Patients and methods: We enrolled 198 participants, including 106 patients with ESRD and 92 controls. Peripheral blood samples were collected from each patient for genetic (rs3732378 and rs3732379 polymorphisms) and immunoenzymatic (fractalkine, CX3CR1, CRP) tests. Results: CX3CR1 and CRP levels were higher in patients with ESRD than in controls (p < 0.05). Fractalkine levels were significantly higher in ESRD patients who were homozygous for the G allele of the rs3732378 polymorphism and for the C allele of the rs3732379 polymorphism than in homozygous controls. Moreover, carriers of these alleles among patients with ESRD had significantly higher CX3CR1 levels than controls. Conclusions: The G allele of the rs3732378 polymorphism and the C allele of the rs3732379 polymorphism of the CX3CR1 gene are associated with higher CX3CL1 and CX3CR1 levels. Our study suggests that CX3CR1 gene polymorphisms could be potentially involved in the pathogenesis of ESRD, but the study needs to be replicated in a larger population with a longitudinal follow-up study. Identification of genetic factors associated with inflammation in ESRD may contribute to the development of targeted gene therapies in the future. View Full-Text
Keywords: fractalkine; fractalkine receptor; inflammation; end-stage renal disease fractalkine; fractalkine receptor; inflammation; end-stage renal disease
MDPI and ACS Style

Woźny, Ł.; Żywiec, J.; Gosek, K.; Kuźniewicz, R.; Górczyńska-Kosiorz, S.; Trautsolt, W.; Śnit, M.; Grzeszczak, W. Association of CX3CR1 Gene Polymorphisms with Fractalkine, Fractalkine Receptor, and C-Reactive Protein Levels in Patients with Kidney Failure. Int. J. Environ. Res. Public Health 2021, 18, 2202. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18042202

AMA Style

Woźny Ł, Żywiec J, Gosek K, Kuźniewicz R, Górczyńska-Kosiorz S, Trautsolt W, Śnit M, Grzeszczak W. Association of CX3CR1 Gene Polymorphisms with Fractalkine, Fractalkine Receptor, and C-Reactive Protein Levels in Patients with Kidney Failure. International Journal of Environmental Research and Public Health. 2021; 18(4):2202. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18042202

Chicago/Turabian Style

Woźny, Łukasz, Joanna Żywiec, Katarzyna Gosek, Roman Kuźniewicz, Sylwia Górczyńska-Kosiorz, Wanda Trautsolt, Mirosław Śnit, and Władysław Grzeszczak. 2021. "Association of CX3CR1 Gene Polymorphisms with Fractalkine, Fractalkine Receptor, and C-Reactive Protein Levels in Patients with Kidney Failure" International Journal of Environmental Research and Public Health 18, no. 4: 2202. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18042202

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