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Systematic Review

Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?

1
Unit of Dermatology, Mariano Santo Hospital, 87100 Cosenza, Italy
2
Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Received: 30 April 2021 / Revised: 20 June 2021 / Accepted: 22 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue Management of Cutaneous Squamous Cell Carcinoma Patients)
Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy. View Full-Text
Keywords: squamous cell carcinoma; imiquimod; 5-fluorouracil squamous cell carcinoma; imiquimod; 5-fluorouracil
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MDPI and ACS Style

Bennardo, L.; Bennardo, F.; Giudice, A.; Passante, M.; Dastoli, S.; Morrone, P.; Provenzano, E.; Patruno, C.; Nisticò, S.P. Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far? Curr. Oncol. 2021, 28, 2317-2325. https://0-doi-org.brum.beds.ac.uk/10.3390/curroncol28040213

AMA Style

Bennardo L, Bennardo F, Giudice A, Passante M, Dastoli S, Morrone P, Provenzano E, Patruno C, Nisticò SP. Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far? Current Oncology. 2021; 28(4):2317-2325. https://0-doi-org.brum.beds.ac.uk/10.3390/curroncol28040213

Chicago/Turabian Style

Bennardo, Luigi, Francesco Bennardo, Amerigo Giudice, Maria Passante, Stefano Dastoli, Pietro Morrone, Eugenio Provenzano, Cataldo Patruno, and Steven P. Nisticò 2021. "Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?" Current Oncology 28, no. 4: 2317-2325. https://0-doi-org.brum.beds.ac.uk/10.3390/curroncol28040213

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