Next Article in Journal
What Should We Recommend for Colorectal Cancer Screening in Adults Aged 75 and Older?
Previous Article in Journal
Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes?
Article

WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma

1
Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
2
Department of Pathology, Faculty of Medicine Ramathibodi Hospital Mahidol University, Bangkok 10400, Thailand
3
N Health Pathology Laboratory, Bangkok 10310, Thailand
4
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Received: 4 June 2021 / Revised: 3 July 2021 / Accepted: 6 July 2021 / Published: 8 July 2021
Background: Members of the Wnt signaling pathway have been shown to play a role in nasopharyngeal carcinoma (NPC) progression. Aim: The purpose of this study was to investigate WNT8B protein expression in NPC patients using tissue microarray (TMA) analysis and to evaluate its correlation with patient survival and clinical parameters. Methods: A total of 82 NPC cases, together with six normal nasopharyngeal tissue samples, were targeted to construct the TMA blocks. The WNT8B protein expression was evaluated by immunohistochemistry and its correlation to the clinicopathological features was investigated. Results: Sixty-two of 82 (75.6%) cases exhibited high WNT8B protein expression while 20/82 (24.4%) cases appeared to have low WNT8B expression. The univariate analysis revealed that systemic metastasis was associated with patient 5-year survival. The multivariate Cox proportional hazard regression analysis showed that WNT8B expression and systemic metastasis were significantly associated with the survival of NPC patients. Furthermore, there was no correlation found between the WNT8B protein expression and other clinicopathological parameters. Conclusion: Our results suggest that the expression of WNT8B is associated with NPC patients’ survival and could serve as an independent prognostic factor for NPC patients. View Full-Text
Keywords: WNT8B; nasopharyngeal carcinoma; Wnt signaling; prognosis WNT8B; nasopharyngeal carcinoma; Wnt signaling; prognosis
Show Figures

Figure 1

MDPI and ACS Style

Ngernsombat, C.; Prattapong, P.; Larbcharoensub, N.; Khotthong, K.; Janvilisri, T. WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma. Curr. Oncol. 2021, 28, 2529-2539. https://0-doi-org.brum.beds.ac.uk/10.3390/curroncol28040230

AMA Style

Ngernsombat C, Prattapong P, Larbcharoensub N, Khotthong K, Janvilisri T. WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma. Current Oncology. 2021; 28(4):2529-2539. https://0-doi-org.brum.beds.ac.uk/10.3390/curroncol28040230

Chicago/Turabian Style

Ngernsombat, Chawalit, Pongphol Prattapong, Noppadol Larbcharoensub, Krittika Khotthong, and Tavan Janvilisri. 2021. "WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma" Current Oncology 28, no. 4: 2529-2539. https://0-doi-org.brum.beds.ac.uk/10.3390/curroncol28040230

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop