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Review

Does the Addition of Zinc Oxide Nanoparticles Improve the Antibacterial Properties of Direct Dental Composite Resins? A Systematic Review

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College of Medicine and Dentistry, James Cook University, 14-88 McGregor Road, Smithfield, QLD 4878, Australia
2
College of Science and Engineering, James Cook University, 14-88 McGregor Road, Smithfield, QLD 4878, Australia
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School of Dentistry & Health Sciences, Charles Sturt University Orange Campus, P.O. Box 883, Orange, NSW 2800, Australia
4
Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia
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Centre for Molecular Therapeutics, James Cook University, Cairns, QLD 4878, Australia
*
Author to whom correspondence should be addressed.
Received: 28 October 2020 / Revised: 9 December 2020 / Accepted: 21 December 2020 / Published: 24 December 2020
(This article belongs to the Special Issue Novel Biomaterials and Technology for Dental Clinical Applications)
A promising approach to improve the poor antibacterial properties of dental composite resins has been the addition of metal oxide nanoparticles into the resin matrix. This systematic review aimed to determine whether the addition of zinc oxide nanoparticles (ZnO-NPs) improves the antibacterial properties of direct dental composite resins. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered with the PROSPERO database: CRD42019131383. A systematic literature search was conducted using the following databases: Medline (Ovid), the Cochrane Library, SCOPUS, CINAHL, Web of Science, Trove, Google Scholar, World Cat, and OpenGrey. The initial search retrieved 3178 results, which were then screened against inclusion and exclusion criteria, resulting in a total of four studies that were eligible for qualitative synthesis within this review. All the included studies were in vitro non-randomized post-test design experimental studies. A lack of congruity in the results obtained from these studies that used different tests to evaluate antibacterial activity was evident. Although some studies demonstrated a significant improvement of antibacterial properties in composites containing at least 1% ZnO-NPs (wt %), they are unlikely to present any clear clinical advantage due to the short lifetime of observed antibacterial properties. View Full-Text
Keywords: antibacterial agents; composite resin; zinc oxide; nanoparticles; zinc oxide nanoparticles; dentistry; dental materials; systematic review antibacterial agents; composite resin; zinc oxide; nanoparticles; zinc oxide nanoparticles; dentistry; dental materials; systematic review
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MDPI and ACS Style

Arun, D.; Adikari Mudiyanselage, D.; Gulam Mohamed, R.; Liddell, M.; Monsur Hassan, N.M.; Sharma, D. Does the Addition of Zinc Oxide Nanoparticles Improve the Antibacterial Properties of Direct Dental Composite Resins? A Systematic Review. Materials 2021, 14, 40. https://0-doi-org.brum.beds.ac.uk/10.3390/ma14010040

AMA Style

Arun D, Adikari Mudiyanselage D, Gulam Mohamed R, Liddell M, Monsur Hassan NM, Sharma D. Does the Addition of Zinc Oxide Nanoparticles Improve the Antibacterial Properties of Direct Dental Composite Resins? A Systematic Review. Materials. 2021; 14(1):40. https://0-doi-org.brum.beds.ac.uk/10.3390/ma14010040

Chicago/Turabian Style

Arun, Divya, Dulanja Adikari Mudiyanselage, Rumana Gulam Mohamed, Michael Liddell, Nur M. Monsur Hassan, and Dileep Sharma. 2021. "Does the Addition of Zinc Oxide Nanoparticles Improve the Antibacterial Properties of Direct Dental Composite Resins? A Systematic Review" Materials 14, no. 1: 40. https://0-doi-org.brum.beds.ac.uk/10.3390/ma14010040

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