Next Article in Journal / Special Issue
Structure and Function of the T4 Spackle Protein Gp61.3
Previous Article in Journal
Identification of Modulators of HIV-1 Proviral Transcription from a Library of FDA-Approved Pharmaceuticals
Previous Article in Special Issue
Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure
Review

Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies

1
Molecular Microbiology and Structural Biochemistry, University of Lyon, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France
2
Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
3
Department of Medicine II/Molecular Biology, Medical Center, University Hospital Freiburg, Albert-Ludwigs-University, 79106 Freiburg, Germany
*
Authors to whom correspondence should be addressed.
Received: 28 August 2020 / Revised: 21 September 2020 / Accepted: 21 September 2020 / Published: 24 September 2020
(This article belongs to the Special Issue In Memory of Michael Rossmann)
Structural virology reveals the architecture underlying infection. While notably electron microscopy images have provided an atomic view on viruses which profoundly changed our understanding of these assemblies incapable of independent life, spectroscopic techniques like NMR enter the field with their strengths in detailed conformational analysis and investigation of dynamic behavior. Typically, the large assemblies represented by viral particles fall in the regime of biological high-resolution solid-state NMR, able to follow with high sensitivity the path of the viral proteins through their interactions and maturation steps during the viral life cycle. We here trace the way from first solid-state NMR investigations to the state-of-the-art approaches currently developing, including applications focused on HIV, HBV, HCV and influenza, and an outlook to the possibilities opening in the coming years. View Full-Text
Keywords: structure; solid-state NMR; viral proteins; capsids; membrane proteins structure; solid-state NMR; viral proteins; capsids; membrane proteins
Show Figures

Graphical abstract

MDPI and ACS Style

Lecoq, L.; Fogeron, M.-L.; Meier, B.H.; Nassal, M.; Böckmann, A. Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies. Viruses 2020, 12, 1069. https://0-doi-org.brum.beds.ac.uk/10.3390/v12101069

AMA Style

Lecoq L, Fogeron M-L, Meier BH, Nassal M, Böckmann A. Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies. Viruses. 2020; 12(10):1069. https://0-doi-org.brum.beds.ac.uk/10.3390/v12101069

Chicago/Turabian Style

Lecoq, Lauriane, Marie-Laure Fogeron, Beat H. Meier, Michael Nassal, and Anja Böckmann. 2020. "Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies" Viruses 12, no. 10: 1069. https://0-doi-org.brum.beds.ac.uk/10.3390/v12101069

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop