Next Article in Journal
A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters
Next Article in Special Issue
Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections
Previous Article in Journal
Special Issue: Bovine Viral Diarrhea Virus and Related Pestiviruses
Previous Article in Special Issue
House Dust Mite Exposure Causes Increased Susceptibility of Nasal Epithelial Cells to Adenovirus Infection
Review

Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs

Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Received: 29 September 2020 / Revised: 15 October 2020 / Accepted: 16 October 2020 / Published: 19 October 2020
(This article belongs to the Special Issue Adenovirus Pathogenesis)
Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory, ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an advantage of viral small non-coding RNAs (sncRNAs), which have multiple roles during the virus lifecycle. Three of the best-characterized HAdV sncRNAs; VA RNA, mivaRNA and MLP-TSS-sRNA will be discussed in the present review. Even though VA RNA has been extensively characterized during the last 60 years, this multifunctional molecule continues to surprise us as more of its structural secrets unfold. Likely, the recent developments on mivaRNA and MLP-TSS-sRNA synthesis and function highlight the importance of these sncRNA in virus replication. Collectively, we will summarize the old and new knowledge about these three viral sncRNAs with focus on their synthesis, structure and functions. View Full-Text
Keywords: human adenovirus; sncRNA; VA RNA; mivaRNA; PKR; Dicer; MLP-TSS-sRNA; miRISC human adenovirus; sncRNA; VA RNA; mivaRNA; PKR; Dicer; MLP-TSS-sRNA; miRISC
Show Figures

Figure 1

MDPI and ACS Style

Punga, T.; Darweesh, M.; Akusjärvi, G. Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs. Viruses 2020, 12, 1182. https://0-doi-org.brum.beds.ac.uk/10.3390/v12101182

AMA Style

Punga T, Darweesh M, Akusjärvi G. Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs. Viruses. 2020; 12(10):1182. https://0-doi-org.brum.beds.ac.uk/10.3390/v12101182

Chicago/Turabian Style

Punga, Tanel, Mahmoud Darweesh, and Göran Akusjärvi. 2020. "Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs" Viruses 12, no. 10: 1182. https://0-doi-org.brum.beds.ac.uk/10.3390/v12101182

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop