Next Article in Journal
Deformed Wing Virus in Two Widespread Invasive Ants: Geographical Distribution, Prevalence, and Phylogeny
Next Article in Special Issue
Camelid Inoculation with Middle East Respiratory Syndrome Coronavirus: Experimental Models of Reservoir Host Infection
Previous Article in Journal
Genomic Diversity and Evolution of Quasispecies in Newcastle Disease Virus Infections
Previous Article in Special Issue
Treatment with Exogenous Trypsin Expands In Vitro Cellular Tropism of the Avian Coronavirus Infectious Bronchitis Virus
Commentary

Placental Pathology of COVID-19 with and without Fetal and Neonatal Infection: Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2

1
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
2
Pathology Unit and Medical Genetics Laboratory, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy
*
Author to whom correspondence should be addressed.
Received: 29 October 2020 / Revised: 12 November 2020 / Accepted: 13 November 2020 / Published: 15 November 2020
(This article belongs to the Special Issue Pathogenesis of Human and Animal Coronaviruses)
The mechanism(s) by which neonates testing positive for coronavirus disease 2019 (COVID-19) acquire their infection has been largely unknown. Transmission of the etiological agent, SARS-CoV-2, from mother to infant has been suspected but has been difficult to confirm. This communication summarizes the spectrum of pathology findings from pregnant women with COVID-19 based upon the infection status of their infants and addresses the potential interpretation of these results in terms of the effects of SARS-CoV-2 on the placenta and the pathophysiology of maternal-fetal infection. Placentas from pregnant women with COVID-19 and uninfected neonates show significant variability in the spectrum of pathology findings. In contrast, placentas from infected maternal-neonatal dyads are characterized by the finding of mononuclear cell inflammation of the intervillous space, termed chronic histiocytic intervillositis, together with syncytiotrophoblast necrosis. These placentas show prominent positivity of syncytiotrophoblast by SARS-CoV-2, fulfilling the published criteria for transplacental viral transmission as confirmed in fetal cells through identification of viral antigens by immunohistochemistry or viral nucleic acid using RNA in situ hybridization. The co-occurrence of chronic histiocytic intervillositis and trophoblast necrosis appears to be a risk factor for placental infection with SARS-CoV-2 as well as for maternal-fetal viral transmission, and suggests a potential mechanism by which the coronavirus can breach the maternal-fetal interface. View Full-Text
Keywords: COVID-19; maternal COVID-19 infection; fetal COVID-19 infection; placental COVID-19 infection; trophoblast necrosis; chronic histiocytic intervillositis; placental risk factors; neonatal COVID-19 infection; vertical transmission; placental pathology; SARS-CoV-2; maternal-fetal COVID-19; transplacental COVID-19 infection COVID-19; maternal COVID-19 infection; fetal COVID-19 infection; placental COVID-19 infection; trophoblast necrosis; chronic histiocytic intervillositis; placental risk factors; neonatal COVID-19 infection; vertical transmission; placental pathology; SARS-CoV-2; maternal-fetal COVID-19; transplacental COVID-19 infection
Show Figures

Figure 1

MDPI and ACS Style

Schwartz, D.A.; Morotti, D. Placental Pathology of COVID-19 with and without Fetal and Neonatal Infection: Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2. Viruses 2020, 12, 1308. https://0-doi-org.brum.beds.ac.uk/10.3390/v12111308

AMA Style

Schwartz DA, Morotti D. Placental Pathology of COVID-19 with and without Fetal and Neonatal Infection: Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2. Viruses. 2020; 12(11):1308. https://0-doi-org.brum.beds.ac.uk/10.3390/v12111308

Chicago/Turabian Style

Schwartz, David A.; Morotti, Denise. 2020. "Placental Pathology of COVID-19 with and without Fetal and Neonatal Infection: Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2" Viruses 12, no. 11: 1308. https://0-doi-org.brum.beds.ac.uk/10.3390/v12111308

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop