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Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections
Review

Adenovirus—Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes

Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS (French National Centre for Scientific Research), 34090 Montpellier, France
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Author to whom correspondence should be addressed.
Academic Editors: Annasara Lenman and Niklas Arnberg
Received: 16 October 2020 / Revised: 23 November 2020 / Accepted: 24 November 2020 / Published: 26 November 2020
(This article belongs to the Special Issue Adenovirus Pathogenesis)
The aim of this review is to highlight how, in a syngeneic system, human mononuclear phagocytes respond to environments containing human adenovirus (HAdV) and soluble extracellular proteins that influence their innate immune response. Soluble extracellular proteins, including immunoglobulins, blood clotting factors, proteins of the complement system, and/or antimicrobial peptides (AMPs) can exert direct effects by binding to a virus capsid that modifies interactions with pattern recognition receptors and downstream signaling. In addition, the presence, generation, or secretion of extracellular proteins can indirectly influence the response to HAdVs via the activation and recruitment of cells at the site of infection. View Full-Text
Keywords: adenovirus; innate immunity; antibody; antimicrobial peptide; coagulation factor; complement; dendritic cell; host defense peptide; alarmin adenovirus; innate immunity; antibody; antimicrobial peptide; coagulation factor; complement; dendritic cell; host defense peptide; alarmin
MDPI and ACS Style

Chéneau, C.; Kremer, E.J. Adenovirus—Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes. Viruses 2020, 12, 1351. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121351

AMA Style

Chéneau C, Kremer EJ. Adenovirus—Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes. Viruses. 2020; 12(12):1351. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121351

Chicago/Turabian Style

Chéneau, Coraline, and Eric J. Kremer 2020. "Adenovirus—Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes" Viruses 12, no. 12: 1351. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121351

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