Next Article in Journal
Assessment of Viral Targeted Sequence Capture Using Nanopore Sequencing Directly from Clinical Samples
Next Article in Special Issue
Camelid Inoculation with Middle East Respiratory Syndrome Coronavirus: Experimental Models of Reservoir Host Infection
Previous Article in Journal
Valproic Acid and Its Amidic Derivatives as New Antivirals against Alphaherpesviruses
Previous Article in Special Issue
COVID-19 and School Activities in Italy
Article

Persisting Neutralizing Activity to SARS-CoV-2 over Months in Sera of COVID-19 Patients

1
Paediatric Endocrinolgy, University Children’s Hospital, Hoppe-Seyler-Str. 1, 72076 Tuebingen, Germany
2
Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH, Aspenhaustr. 25, 72770 Reutlingen, Germany
3
Institute for Medical Virology and Epidemiology, University Hospital Tuebingen, Elfriede-Aulhorn-Str. 6, 72076 Tuebingen, Germany
4
4base Lab AG Advanced Molecular Analysis, Aspenhaustr. 25, 72770 Reutlingen, Germany
5
Pediatric Practice, Kapuzinerberg 17, 71263 Weil der Stadt, Germany
6
Institute for Pathology and Neuropathology, University Hospital Tuebingen, Liebermeisterstr. 8, 72076 Tuebingen, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Luis Martinez-Sobrido
Received: 9 November 2020 / Revised: 23 November 2020 / Accepted: 24 November 2020 / Published: 27 November 2020
(This article belongs to the Collection Coronaviruses)
The relationship between the nasopharyngeal virus load, IgA and IgG antibodies to both the S1-RBD-protein and the N-protein, as well as the neutralizing activity (NAbs) against SARS-CoV-2 in the blood of moderately afflicted COVID-19 patients, needs further longitudinal investigation. Several new serological methods to examine these parameters were developed, validated and applied in three patients of a family which underwent an ambulatory course of COVID-19 for six months. The virus load had almost completely disappeared after about four weeks. Serum IgA levels to the S1-RBD-protein and, to a lesser extent, to the N-protein, peaked about three weeks after clinical disease onset but declined soon thereafter. IgG levels rose continuously, reaching a plateau at approximately six weeks, and stayed elevated over the observation period. Virus-neutralizing activity reached a peak about 4 weeks after disease onset but dropped slowly. The longitudinal associations of virus neutralization and the serological immune response suggest immunity in patients even after a mild clinical course of COVID-19. View Full-Text
Keywords: COVID-19; SARS-CoV-2 RT-qPCR; anti-SARS-CoV-2 antibodies; SARS-CoV-2 S1-RDB protein; SARS-CoV-2 N-protein; SARS-CoV-2 neutralizing activity COVID-19; SARS-CoV-2 RT-qPCR; anti-SARS-CoV-2 antibodies; SARS-CoV-2 S1-RDB protein; SARS-CoV-2 N-protein; SARS-CoV-2 neutralizing activity
Show Figures

Figure 1

MDPI and ACS Style

Flehmig, B.; Schindler, M.; Ruetalo, N.; Businger, R.; Bayer, M.; Haage, A.; Kirchner, T.; Klingel, K.; Normann, A.; Pridzun, L.; Tougianidou, D.; Ranke, M.B. Persisting Neutralizing Activity to SARS-CoV-2 over Months in Sera of COVID-19 Patients. Viruses 2020, 12, 1357. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121357

AMA Style

Flehmig B, Schindler M, Ruetalo N, Businger R, Bayer M, Haage A, Kirchner T, Klingel K, Normann A, Pridzun L, Tougianidou D, Ranke MB. Persisting Neutralizing Activity to SARS-CoV-2 over Months in Sera of COVID-19 Patients. Viruses. 2020; 12(12):1357. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121357

Chicago/Turabian Style

Flehmig, Bertram; Schindler, Michael; Ruetalo, Natalia; Businger, Ramona; Bayer, Manfred; Haage, Angelika; Kirchner, Thomas; Klingel, Karin; Normann, Andrea; Pridzun, Lutz; Tougianidou, Despina; Ranke, Michael B. 2020. "Persisting Neutralizing Activity to SARS-CoV-2 over Months in Sera of COVID-19 Patients" Viruses 12, no. 12: 1357. https://0-doi-org.brum.beds.ac.uk/10.3390/v12121357

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop