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Dysregulated Interferon Response Underlying Severe COVID-19

Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, 3500 John A. Merritt Boulevard, Nashville, TN 37209, USA
Author to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Andrew Davidson
Received: 27 October 2020 / Revised: 6 December 2020 / Accepted: 9 December 2020 / Published: 13 December 2020
(This article belongs to the Special Issue Pathogenesis of Human and Animal Coronaviruses)
Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an autonomous antiviral state, restrict the virus infection, and prevent COVID-19 progression. Inborn genetic flaws and autoreactive antibodies that block IFN response have been significantly associated with about 14% of patients with life-threatening COVID-19 pneumonia. In most severe COVID-19 patients without genetic errors in IFN-relevant gene loci, IFN dysregulation is progressively worsened and associated with the situation of pro-inflammation and immunopathy, which is prone to autoimmunity. In addition, the high correlation of severe COVID-19 with seniority, males, and individuals with pre-existing comorbidities will be plausibly explained by the coincidence of IFN aberrance in these situations. Collectively, current studies call for a better understanding of the IFN response regarding the spatiotemporal determination and subtype-specificity against SARS-CoV-2 infections, which are warranted to devise IFN-related prophylactics and therapies. View Full-Text
Keywords: COVID-19; interferons; interferon signaling; SARS-CoV-2; immunopathy COVID-19; interferons; interferon signaling; SARS-CoV-2; immunopathy
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MDPI and ACS Style

Lopez, L.; Sang, P.C.; Tian, Y.; Sang, Y. Dysregulated Interferon Response Underlying Severe COVID-19. Viruses 2020, 12, 1433.

AMA Style

Lopez L, Sang PC, Tian Y, Sang Y. Dysregulated Interferon Response Underlying Severe COVID-19. Viruses. 2020; 12(12):1433.

Chicago/Turabian Style

Lopez, LeAnn; Sang, Peter C.; Tian, Yun; Sang, Yongming. 2020. "Dysregulated Interferon Response Underlying Severe COVID-19" Viruses 12, no. 12: 1433.

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