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Article

A Novel Role for PX, a Structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-Inducer in Leghorn Male Hepatocellular Cell

1
Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
2
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
Received: 31 January 2020 / Revised: 16 February 2020 / Accepted: 16 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue Adenovirus Pathogenesis)
Hydropericardium-Hepatitis Syndrome (HHS) caused by Fowl Adenovirus Serotype 4 (FAdV4) infection is a severe threat to the poultry industry worldwide, especially in China since 2015. Recent studies show that FAdV4 induces liver injury through apoptosis. However, the underlying molecular mechanism is still unclear. We report here that FAdV4 infection caused apoptosis in Leghorn male hepatocellular (LMH) cells and that PX, a structural protein of FAdV4, acted as a major viral factor inducing apoptosis. Furthermore, the nuclear localization of PX is determined by the R/K regions of PX and required for PX-induced apoptosis. Moreover, alanines 11 and 129 of PX are crucial to PX-induced apoptosis. Inhibition of FAdV4-induced apoptosis by caspase inhibitors retarded viral replication, suggesting that PX serves as a virulence factor for FAdV4 infection, which may further our understandings of the pathogenesis of FAdV4 infection. View Full-Text
Keywords: FAdV4; PX; nuclear localization; apoptosis; viral replication FAdV4; PX; nuclear localization; apoptosis; viral replication
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MDPI and ACS Style

Zhao, M.; Duan, X.; Wang, Y.; Gao, L.; Cao, H.; Li, X.; Zheng, S.J. A Novel Role for PX, a Structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-Inducer in Leghorn Male Hepatocellular Cell. Viruses 2020, 12, 228. https://0-doi-org.brum.beds.ac.uk/10.3390/v12020228

AMA Style

Zhao M, Duan X, Wang Y, Gao L, Cao H, Li X, Zheng SJ. A Novel Role for PX, a Structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-Inducer in Leghorn Male Hepatocellular Cell. Viruses. 2020; 12(2):228. https://0-doi-org.brum.beds.ac.uk/10.3390/v12020228

Chicago/Turabian Style

Zhao, Mingliang, Xueyan Duan, Yongqiang Wang, Li Gao, Hong Cao, Xiaoqi Li, and Shijun J. Zheng 2020. "A Novel Role for PX, a Structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-Inducer in Leghorn Male Hepatocellular Cell" Viruses 12, no. 2: 228. https://0-doi-org.brum.beds.ac.uk/10.3390/v12020228

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