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Article

The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals

1
Nebraska Center for Virology and School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
2
Ocean Road Cancer Institute, Dar es Salaam 3592, Tanzania
3
Muhimbili University of Health and Allied Sciences, Dar es Salaam 65001, Tanzania
*
Authors to whom correspondence should be addressed.
Received: 3 January 2020 / Revised: 14 February 2020 / Accepted: 23 February 2020 / Published: 26 February 2020
(This article belongs to the Section Animal Viruses)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS), one of the most prevalent cancers of people living with HIV/AIDS in sub-Saharan Africa. The seroprevalence for KSHV is high in the region, and no prophylactic vaccine against the virus is available. In this study, we characterized the antigenic targets of KSHV-specific neutralizing antibodies (nAbs) in asymptomatic KSHV-infected individuals and KS patients with high nAbs titers. We quantified the extent to which various KSHV envelope glycoproteins (gB, ORF28, ORF68, gH, gL, gM, gN and gpK8.1) adsorbed/removed KSHV-specific nAbs from the plasma of infected individuals. Our study revealed that plasma from a majority of KSHV neutralizers recognizes multiple viral glycoproteins. Moreover, the breadth of nAbs responses against these viral glycoproteins varies among endemic KS, epidemic KS and asymptomatic KSHV-infected individuals. Importantly, among the KSHV glycoproteins, the gH/gL complex, but neither gH nor gL alone, showed the highest adsorption of KSHV-specific nAbs. This activity was detected in 80% of the KSHV-infected individuals regardless of their KS status. The findings suggest that the gH/gL complex is the predominant antigenic determinant of KSHV-specific nAbs. Therefore, gH/gL is a potential target for development of KSHV prophylactic vaccines. View Full-Text
Keywords: KSHV; KS; glycoproteins; gH; gL; neutralizing antibodies KSHV; KS; glycoproteins; gH; gL; neutralizing antibodies
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MDPI and ACS Style

Mortazavi, Y.; Lidenge, S.J.; Tran, T.; West, J.T.; Wood, C.; Tso, F.Y. The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals. Viruses 2020, 12, 256. https://0-doi-org.brum.beds.ac.uk/10.3390/v12030256

AMA Style

Mortazavi Y, Lidenge SJ, Tran T, West JT, Wood C, Tso FY. The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals. Viruses. 2020; 12(3):256. https://0-doi-org.brum.beds.ac.uk/10.3390/v12030256

Chicago/Turabian Style

Mortazavi, Yasaman, Salum J. Lidenge, Tara Tran, John T. West, Charles Wood, and For Y. Tso 2020. "The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals" Viruses 12, no. 3: 256. https://0-doi-org.brum.beds.ac.uk/10.3390/v12030256

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