Next Article in Journal / Special Issue
Prognostic Value of Cardiovascular Biomarkers in COVID-19: A Review
Previous Article in Journal
Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2’-O-Methylation of Viral RNA
Previous Article in Special Issue
Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
Review

SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions

1
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
2
The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada
3
Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
4
Department of Microbiology & Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
5
Department of Food, Nutrition and Health, United Arab Emirates University, Al Ain, UAE
6
Ministry of Health and Prevention, Dubai, UAE
7
Department of Biomedical Engineering, Healthcare Engineering Innovation Center (HEIC), Khalifa University, Abu Dhabi, UAE
8
Viral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Received: 31 March 2020 / Revised: 7 May 2020 / Accepted: 7 May 2020 / Published: 10 May 2020
(This article belongs to the Special Issue Pathogenesis of Human and Animal Coronaviruses)
The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respiratory distress, and fatality. To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development. Therefore, this review provides a comprehensive overview of COVID-19 epidemiology, genomic etiology, findings from recent transcriptomic map analysis, viral-human protein interactions, molecular diagnostics, and the current status of vaccine and novel therapeutic intervention development. Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment. View Full-Text
Keywords: SARS-CoV-2; COVID-19; coronavirus; pandemic; viral genomics SARS-CoV-2; COVID-19; coronavirus; pandemic; viral genomics
Show Figures

Figure 1

MDPI and ACS Style

Uddin, M.; Mustafa, F.; Rizvi, T.A.; Loney, T.; Al Suwaidi, H.; Al-Marzouqi, A.H.H.; Kamal Eldin, A.; Alsabeeha, N.; Adrian, T.E.; Stefanini, C.; Nowotny, N.; Alsheikh-Ali, A.; Senok, A.C. SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions. Viruses 2020, 12, 526. https://0-doi-org.brum.beds.ac.uk/10.3390/v12050526

AMA Style

Uddin M, Mustafa F, Rizvi TA, Loney T, Al Suwaidi H, Al-Marzouqi AHH, Kamal Eldin A, Alsabeeha N, Adrian TE, Stefanini C, Nowotny N, Alsheikh-Ali A, Senok AC. SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions. Viruses. 2020; 12(5):526. https://0-doi-org.brum.beds.ac.uk/10.3390/v12050526

Chicago/Turabian Style

Uddin, Mohammed; Mustafa, Farah; Rizvi, Tahir A.; Loney, Tom; Al Suwaidi, Hanan; Al-Marzouqi, Ahmed H.H.; Kamal Eldin, Afaf; Alsabeeha, Nabeel; Adrian, Thomas E.; Stefanini, Cesare; Nowotny, Norbert; Alsheikh-Ali, Alawi; Senok, Abiola C. 2020. "SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions" Viruses 12, no. 5: 526. https://0-doi-org.brum.beds.ac.uk/10.3390/v12050526

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop