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The Dynamic Life of Virus Capsids

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, 301 University Boulevard, Route 0645, Galveston, TX 77555, USA
Author to whom correspondence should be addressed.
Received: 15 May 2020 / Revised: 1 June 2020 / Accepted: 2 June 2020 / Published: 5 June 2020
(This article belongs to the Special Issue In Memory of Michael Rossmann)
Protein-shelled viruses have been thought as “tin cans” that merely carry the genomic cargo from cell to cell. However, through the years, it has become clear that viruses such as rhinoviruses and caliciviruses are active and dynamic structures waiting for the right environmental cues to deliver their genomic payload to the host cell. In the case of human rhinoviruses, the capsid has empty cavities that decrease the energy required to cause conformational changes, resulting in the capsids “breathing”, waiting for the moment when the receptor binds for it to release its genome. Most strikingly, the buried N-termini of VP1 and VP4 are transiently exposed during this process. A more recent example of a “living” protein capsid is mouse norovirus (MNV). This family of viruses have a large protruding (P) domain that is loosely attached to the shell via a single-polypeptide tether. Small molecules found in the gut, such as bile salts, cause the P domains to rotate and collapse onto the shell surface. Concomitantly, bile alters the conformation of the P domain itself from one that binds antibodies to one that recognizes receptors. In this way, MNV appears to use capsid flexibility to present one face to the immune system and a completely different one to attack the host tissue. Therefore, it appears that even protein-shelled viruses have developed an impressive array of tricks to dodge our immune system and efficiently attack the host. View Full-Text
Keywords: rhinovirus; norovirus; antibodies; flexibility rhinovirus; norovirus; antibodies; flexibility
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MDPI and ACS Style

Sherman, M.B.; Smith, H.Q.; Smith, T.J. The Dynamic Life of Virus Capsids. Viruses 2020, 12, 618.

AMA Style

Sherman MB, Smith HQ, Smith TJ. The Dynamic Life of Virus Capsids. Viruses. 2020; 12(6):618.

Chicago/Turabian Style

Sherman, Michael B., Hong Q. Smith, and Thomas J. Smith 2020. "The Dynamic Life of Virus Capsids" Viruses 12, no. 6: 618.

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