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Review

Extracellular Vesicles in Viral Spread and Antiviral Response

1
Departamento de Biología Molecular, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
2
Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 30 April 2020 / Revised: 1 June 2020 / Accepted: 4 June 2020 / Published: 8 June 2020
(This article belongs to the Special Issue Viruses and Extracellular Vesicles)
Viral spread by both enveloped and non-enveloped viruses may be mediated by extracellular vesicles (EVs), including microvesicles (MVs) and exosomes. These secreted vesicles have been demonstrated to be an efficient mechanism that viruses can use to enter host cells, enhance spread or evade the host immune response. However, the complex interplay between viruses and EVs gives rise to antagonistic biological tasks—to benefit the viruses, enhancing infection and interfering with the immune system or to benefit the host, by mediating anti-viral responses. Exosomes from cells infected with herpes simplex type 1 (HSV-1) may transport viral and host transcripts, proteins and innate immune components. This virus may also use MVs to expand its tropism and evade the host immune response. This review aims to describe the current knowledge about EVs and their participation in viral infection, with a specific focus on the role of exosomes and MVs in herpesvirus infections, particularly that of HSV-1. View Full-Text
Keywords: extracellular vesicles; exosomes; microvesicles; viral spread; herpesvirus; herpes simplex type 1 extracellular vesicles; exosomes; microvesicles; viral spread; herpesvirus; herpes simplex type 1
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MDPI and ACS Style

Bello-Morales, R.; Ripa, I.; López-Guerrero, J.A. Extracellular Vesicles in Viral Spread and Antiviral Response. Viruses 2020, 12, 623. https://0-doi-org.brum.beds.ac.uk/10.3390/v12060623

AMA Style

Bello-Morales R, Ripa I, López-Guerrero JA. Extracellular Vesicles in Viral Spread and Antiviral Response. Viruses. 2020; 12(6):623. https://0-doi-org.brum.beds.ac.uk/10.3390/v12060623

Chicago/Turabian Style

Bello-Morales, Raquel, Inés Ripa, and José A. López-Guerrero 2020. "Extracellular Vesicles in Viral Spread and Antiviral Response" Viruses 12, no. 6: 623. https://0-doi-org.brum.beds.ac.uk/10.3390/v12060623

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