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Review

The Adenovirus Dodecahedron: Beyond the Platonic Story

1
Centre National de la Recherche Scientifique, Université Grenoble Alpes, Commissariat Enérgies Alternatives, Institut de Biologie Structurale, 41 rue des Martyrs, 38042 Grenoble, France
2
Centre National de la Recherche Scientifique, Université Grenoble Alpes, Institut National Polytechnique Grenoble, Technique de l’ingénierie Médicale et de la Complexité, TIMC-IMAG Bât Jean Roget Faculté de Médecine et Pharmacie, 38700 La Tronche, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to work.
Received: 11 June 2020 / Revised: 29 June 2020 / Accepted: 30 June 2020 / Published: 2 July 2020
(This article belongs to the Special Issue Adenovirus Pathogenesis)
Many geometric forms are found in nature, some of them adhering to mathematical laws or amazing aesthetic rules. One of the best-known examples in microbiology is the icosahedral shape of certain viruses with 20 triangular facets and 12 edges. What is less known, however, is that a complementary object displaying 12 faces and 20 edges called a ‘dodecahedron’ can be produced in huge amounts during certain adenovirus replication cycles. The decahedron was first described more than 50 years ago in the human adenovirus (HAdV3) viral cycle. Later on, the expression of this recombinant scaffold, combined with improvements in cryo-electron microscopy, made it possible to decipher the structural determinants underlying their architecture. Recently, this particle, which mimics viral entry, was used to fish the long elusive adenovirus receptor, desmoglein-2, which serves as a cellular docking for some adenovirus serotypes. This breakthrough enabled the understanding of the physiological role played by the dodecahedral particles, showing that icosahedral and dodecahedral particles live more than a simple platonic story. All these points are developed in this review, and the potential use of the dodecahedron in therapeutic development is discussed. View Full-Text
Keywords: adenovirus; dodecahedron; platonic solids; virus like particles; receptors; vaccines; structure; viral spreading adenovirus; dodecahedron; platonic solids; virus like particles; receptors; vaccines; structure; viral spreading
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MDPI and ACS Style

Besson, S.; Vragniau, C.; Vassal-Stermann, E.; Dagher, M.C.; Fender, P. The Adenovirus Dodecahedron: Beyond the Platonic Story. Viruses 2020, 12, 718. https://0-doi-org.brum.beds.ac.uk/10.3390/v12070718

AMA Style

Besson S, Vragniau C, Vassal-Stermann E, Dagher MC, Fender P. The Adenovirus Dodecahedron: Beyond the Platonic Story. Viruses. 2020; 12(7):718. https://0-doi-org.brum.beds.ac.uk/10.3390/v12070718

Chicago/Turabian Style

Besson, Solène, Charles Vragniau, Emilie Vassal-Stermann, Marie C. Dagher, and Pascal Fender. 2020. "The Adenovirus Dodecahedron: Beyond the Platonic Story" Viruses 12, no. 7: 718. https://0-doi-org.brum.beds.ac.uk/10.3390/v12070718

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