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Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors

Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
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Author to whom correspondence should be addressed.
Received: 24 June 2020 / Revised: 4 July 2020 / Accepted: 7 July 2020 / Published: 10 July 2020
(This article belongs to the Special Issue Epigenetics and Viral Infection)
Human papillomaviruses are the causative agents of cervical and other anogenital cancers along with approximately 60% of oropharyngeal cancers. These small double-stranded DNA viruses infect stratified epithelia and link their productive life cycles to differentiation. HPV proteins target cellular factors, such as those involved in DNA damage repair, as well as epigenetic control of host and viral transcription to regulate the productive life cycle. HPVs constitutively activate the ATM and ATR DNA repair pathways and preferentially recruit these proteins to viral genomes to facilitate productive viral replication. In addition, the sirtuin deacetylases along with histone acetyltransferases, including Tip60, are targeted in HPV infections to regulate viral transcription and replication. These pathways provide potential targets for drug therapy to treat HPV-induced disease. View Full-Text
Keywords: HPV; DNA damage; ATM; ATR; sirtuins; Tip60 HPV; DNA damage; ATM; ATR; sirtuins; Tip60
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MDPI and ACS Style

Albert, E.; Laimins, L. Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors. Viruses 2020, 12, 744. https://0-doi-org.brum.beds.ac.uk/10.3390/v12070744

AMA Style

Albert E, Laimins L. Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors. Viruses. 2020; 12(7):744. https://0-doi-org.brum.beds.ac.uk/10.3390/v12070744

Chicago/Turabian Style

Albert, Ekaterina, and Laimonis Laimins. 2020. "Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors" Viruses 12, no. 7: 744. https://0-doi-org.brum.beds.ac.uk/10.3390/v12070744

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