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Review

Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure

by 1,2 and 3,4,*
1
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
2
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
3
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
4
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Received: 4 September 2020 / Revised: 20 September 2020 / Accepted: 21 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue In Memory of Michael Rossmann)
Hemagglutinin (HA) glycoprotein is an important focus of influenza research due to its role in antigenic drift and shift, as well as its receptor binding and membrane fusion functions, which are indispensable for viral entry. Over the past four decades, X-ray crystallography has greatly facilitated our understanding of HA receptor binding, membrane fusion, and antigenicity. The recent advances in cryo-EM have further deepened our comprehension of HA biology. Since influenza HA constantly evolves in natural circulating strains, there are always new questions to be answered. The incessant accumulation of knowledge on the structural biology of HA over several decades has also facilitated the design and development of novel therapeutics and vaccines. This review describes the current status of the field of HA structural biology, how we got here, and what the next steps might be. View Full-Text
Keywords: influenza virus; hemagglutinin; evolution; host receptor binding; sialylated glycans; membrane fusion; antibody; antigenicity; vaccine; escape mutations influenza virus; hemagglutinin; evolution; host receptor binding; sialylated glycans; membrane fusion; antibody; antigenicity; vaccine; escape mutations
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MDPI and ACS Style

Wu, N.C.; Wilson, I.A. Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure. Viruses 2020, 12, 1053. https://0-doi-org.brum.beds.ac.uk/10.3390/v12091053

AMA Style

Wu NC, Wilson IA. Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure. Viruses. 2020; 12(9):1053. https://0-doi-org.brum.beds.ac.uk/10.3390/v12091053

Chicago/Turabian Style

Wu, Nicholas C., and Ian A. Wilson 2020. "Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure" Viruses 12, no. 9: 1053. https://0-doi-org.brum.beds.ac.uk/10.3390/v12091053

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