Viruses, Volume 13, Issue 1 (January 2021) – 142 articles
Cover Story (view full-size image): Stimulated emission depletion image of a porcine alveolar macrophage cell infected with African swine fever virus. Two viral proteins present in the replication area (virus factory) are visualised; the major capsid protein p72 (red) and the structural protein p54 (green). This super-resolution technique clearly shows the ring of capsid protein around these 200 nm virions. The membrane-associated p54 has previously only been seen as a pleomorphic cloud in the factory by confocal microscopy but is seen here to have a reticular nature. At the periphery of the factory, we can see some p54-labelled membrane assembly intermediates feeding into newly formed virions labelled with p72. Image credit Sophie Aicher. View this paper
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