Next Article in Journal
Therapy Implications of Hepatitis C Virus Genetic Diversity
Previous Article in Journal
Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids
Review

The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature

1
SENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, Bahia, Brazil
2
Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Shan-Lu Liu
Received: 10 November 2020 / Revised: 18 December 2020 / Accepted: 24 December 2020 / Published: 29 December 2020
(This article belongs to the Section SARS-CoV-2 and COVID-19)
Diagnostic tests have been considered as the main alternative for the control of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a correct diagnosis allows for decision making when facing the disease, particularly as there is a lack of effective therapeutic protocols and vaccines. Thus, in this review, we summarized the main diagnostic approaches currently available for the diagnosis of SARS-CoV-2 infection in humans based on studies available in article databases. The tests can be organized into two main categories: nucleic acid-based tests, recommended for the initial detection of the virus, and serological tests, recommended for assessing the disease progression. The studies have shown that the performance of diagnostic methods depends on different factors, such as the type of samples and the characteristics of each assay. It was identified that the positivity of the tests is mainly related to the onset of symptoms. We also observed that point-of-care diagnoses are considered as one of the main trends in this area, due to the low-cost and simplicity of the assay; however, the analytical performance must be critically analyzed. Thus, the COVID-19 pandemic has highlighted the critical role of diagnostic technologies in the control of infectious diseases. View Full-Text
Keywords: SARS-CoV-2; COVID-19; diagnostic; molecular testing; serology testing SARS-CoV-2; COVID-19; diagnostic; molecular testing; serology testing
Show Figures

Figure 1

MDPI and ACS Style

Machado, B.A.S.; Hodel, K.V.S.; Barbosa-Júnior, V.G.; Soares, M.B.P.; Badaró, R. The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature. Viruses 2021, 13, 40. https://0-doi-org.brum.beds.ac.uk/10.3390/v13010040

AMA Style

Machado BAS, Hodel KVS, Barbosa-Júnior VG, Soares MBP, Badaró R. The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature. Viruses. 2021; 13(1):40. https://0-doi-org.brum.beds.ac.uk/10.3390/v13010040

Chicago/Turabian Style

Machado, Bruna A.S.; Hodel, Katharine V.S.; Barbosa-Júnior, Valdir G.; Soares, Milena B.P.; Badaró, Roberto. 2021. "The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature" Viruses 13, no. 1: 40. https://0-doi-org.brum.beds.ac.uk/10.3390/v13010040

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop