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Article

ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection

1
Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland
2
Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland
3
Faculty of Social Sciences, Tampere University, 33250 Tampere, Finland
4
Department of Virology, Medicum, University of Helsinki, 00290 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Helle Bielefeldt-Ohmann
Received: 30 September 2021 / Revised: 8 November 2021 / Accepted: 10 November 2021 / Published: 13 November 2021
(This article belongs to the Special Issue Hantavirus Research in Finland)
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982–2017. Patients’ blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (n = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection. View Full-Text
Keywords: Puumala hantavirus; ABO blood groups; rhesus blood groups; capillary leakage; AKI; blood pressure Puumala hantavirus; ABO blood groups; rhesus blood groups; capillary leakage; AKI; blood pressure
MDPI and ACS Style

Tietäväinen, J.; Laine, O.; Mäkelä, S.; Huhtala, H.; Pörsti, I.; Vaheri, A.; Mustonen, J. ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection. Viruses 2021, 13, 2271. https://0-doi-org.brum.beds.ac.uk/10.3390/v13112271

AMA Style

Tietäväinen J, Laine O, Mäkelä S, Huhtala H, Pörsti I, Vaheri A, Mustonen J. ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection. Viruses. 2021; 13(11):2271. https://0-doi-org.brum.beds.ac.uk/10.3390/v13112271

Chicago/Turabian Style

Tietäväinen, Johanna, Outi Laine, Satu Mäkelä, Heini Huhtala, Ilkka Pörsti, Antti Vaheri, and Jukka Mustonen. 2021. "ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection" Viruses 13, no. 11: 2271. https://0-doi-org.brum.beds.ac.uk/10.3390/v13112271

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